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AIRE elisa kit :: Rabbit Autoimmune Regulator ELISA Kit

Scan QR to view Datasheet Catalog #    MBS008137 AIRE elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Autoimmune Regulator (AIRE), ELISA Kit

 Also Known As   

Rabbit Autoimmune Regulator ELISA Kit

 Product Gene Name   

AIRE elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 21; NC_000021.8 (45705721..45718102). Location: 21q22.3
 OMIM    109100
 3D Structure    ModBase 3D Structure for O43918
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 Species Reactivity    Rabbit
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of AIRE elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AIRE purchase    MBS008137 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Autoimmune Regulator (AIRE) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AIRE. The ELISA analytical biochemical technique of the MBS008137 kit is based on AIRE antibody-AIRE antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AIRE antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AIRE. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for AIRE. It may not necessarily be applicable to this product.
 NCBI GI #    3392940
 NCBI GeneID    326
 NCBI Accession #    CAA08759.1 [Other Products]
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 UniProt Primary Accession #    O43918 [Other Products]
 UniProt Secondary Accession #    O43922; O43932; O75745; B2RP50 [Other Products]
 UniProt Related Accession #    O43918 [Other Products]
 Molecular Weight    57,727 Da
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 NCBI Official Full Name    AIRE
 NCBI Official Synonym Full Names    autoimmune regulator
 NCBI Official Symbol    AIRE [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    autoimmune regulator; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
 UniProt Protein Name    Autoimmune regulator
 UniProt Synonym Protein Names   
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
 Protein Family    Autoimmune regulator
 UniProt Gene Name    AIRE [Similar Products]
 UniProt Synonym Gene Names    APECED; APECED protein [Similar Products]
 UniProt Entry Name    AIRE_HUMAN
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 NCBI Summary for AIRE    This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]
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 UniProt Comments for AIRE    AIRE: Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. Defects in AIRE are a cause of autoimmune poly- endocrinopathy candidiasis ectodermal dystrophy (APS1). An autosomal recessive disease characterized by the combination of chronic mucocutaneous candidiasis, hypoparathyroidism and Addison disease. Symptoms of mucocutaneous candidiasis manifest first, followed by hypotension or fatigue occurring as a result of Addison disease. APS1 is associated with other autoimmune disorders including diabetes mellitus, vitiligo, alopecia, hepatitis, pernicious anemia and primary hypothyroidism. Most of the mutations alter the nucleus-cytoplasm distribution of AIRE and disturb its association with nuclear dots and cytoplasmic filaments. Most of the mutations also decrease transactivation of the protein. The HSR domain is responsible for the homomultimerization activity of AIRE. All the missense mutations of the HSR and the SAND domains decrease this activity, but those in other domains do not. The AIRE protein is present in soluble high-molecular-weight complexes. Mutations in the HSR domain and deletion of PHD zinc fingers disturb the formation of these complexes. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytoplasm; nucleus

Molecular Function: identical protein binding; protein binding; zinc ion binding; histone binding; translation regulator activity; chromatin binding

Biological Process: regulation of translation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; immune response; humoral immune response

Disease: Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia
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 Research Articles on AIRE    1. functional characterization of the alternatively spliced AIRE mutation that may explain the pathogenetic role in APS-1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AIRE elisa kitPathways associated with AIRE elisa kit
 Reference Product  PubMed Publications
 FOXN1 elisa kit  >11 publications with AIRE and FOXN1
 PRKDC elisa kit  >4 publications with AIRE and PRKDC
 CREBBP elisa kit  >2 publications with AIRE and CREBBP
 ICA1 elisa kit  >1 publications with AIRE and ICA1
 CDK9 elisa kit  >1 publications with AIRE and CDK9
 Products by Pathway  Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
Diseases associated with AIRE elisa kitOrgans/Tissues associated with AIRE elisa kit
 Disease Name  Pubmed Publications
 Polyendocrinopathies, Autoimmune Antibodies  >202 publications with AIRE and Polyendocrinopathies, Autoimmune
 Candidiasis Antibodies  >188 publications with AIRE and Candidiasis
 Cardiovascular Diseases Antibodies  >76 publications with AIRE and Cardiovascular Diseases
 Heart Diseases Antibodies  >58 publications with AIRE and Heart Diseases
 Lung Diseases Antibodies  >33 publications with AIRE and Lung Diseases
 Inflammation Antibodies  >28 publications with AIRE and Inflammation
 Brain Diseases Antibodies  >28 publications with AIRE and Brain Diseases
 Autoimmune polyendocrinopathy syndrome, type 1 Antibodies  >27 publications with AIRE and Autoimmune polyendocrinopathy syndrome, type 1
 Kidney Diseases Antibodies  >19 publications with AIRE and Kidney Diseases
 Necrosis Antibodies  >18 publications with AIRE and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >259 publications with AIRE and Thymus
 Kidney Antibodies  >28 publications with AIRE and Kidney
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