NP_690605.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,077 Da
NCBI Official Full Name
B-lymphocyte antigen CD20
NCBI Official Synonym Full Names
membrane-spanning 4-domains, subfamily A, member 1
NCBI Official Synonym Symbols
B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16 [Similar Products]
NCBI Protein Information
B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
UniProt Protein Name
B-lymphocyte antigen CD20
UniProt Synonym Protein Names
B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD_antigen: CD20
UniProt Synonym Gene Names
UniProt Entry Name
CD20_HUMAN
NCBI Summary for MS4A1
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
UniProt Comments for MS4A1
MS4A1: This protein may be involved in the regulation of B-cell activation and proliferation. Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the MS4A family.
Protein type: Membrane protein, multi-pass; Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q12
Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane
Molecular Function: epidermal growth factor receptor binding
Biological Process: B cell proliferation; humoral immune response
Disease: Immunodeficiency, Common Variable, 5
Research Articles on MS4A1
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Products associated with MS4A1 elisa kit
Pathways associated with MS4A1 elisa kit
Diseases associated with MS4A1 elisa kit
Organs/Tissues associated with MS4A1 elisa kit
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