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BFGF 4 elisa kit :: Rabbit Basic Fibroblast Growth Factor 4 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS017157 BFGF 4 elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Basic Fibroblast Growth Factor 4 (BFGF 4), ELISA Kit

 Also Known As   

Rabbit Basic Fibroblast Growth Factor 4 ELISA Kit

 Product Gene Name   

BFGF 4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    134920
 3D Structure    ModBase 3D Structure for P09038
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 Species Reactivity    Rabbit
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of BFGF 4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for BFGF 4 purchase    MBS017157 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Basic Fibroblast Growth Factor 4 (BFGF 4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing BFGF 4. The ELISA analytical biochemical technique of the MBS017157 kit is based on BFGF 4 antibody-BFGF 4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BFGF 4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BFGF 4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for BFGF 4. It may not necessarily be applicable to this product.
 NCBI GI #    56068041
 NCBI GeneID    2247
 NCBI Accession #    AAV70487.1 [Other Products]
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 UniProt Primary Accession #    P09038 [Other Products]
 UniProt Secondary Accession #    O00527; P78443; Q16443; Q5PY50; Q7KZ11; Q7KZ72; Q9UC54; Q9UCS5; Q9UCS6; A4LBB8 [Other Products]
 UniProt Related Accession #    P09038 [Other Products]
 Molecular Weight    30,770 Da
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 NCBI Official Full Name    basic fibroblast growth factor, partial
 NCBI Official Synonym Full Names    fibroblast growth factor 2 (basic)
 NCBI Official Symbol    FGF2 [Similar Products]
 NCBI Official Synonym Symbols   
BFGF; FGFB; FGF-2; HBGF-2
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 2; prostatropin; heparin-binding growth factor 2; basic fibroblast growth factor bFGF
 UniProt Protein Name    Fibroblast growth factor 2
 UniProt Synonym Protein Names   
Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2
 UniProt Gene Name    FGF2 [Similar Products]
 UniProt Synonym Gene Names    FGFB; FGF-2; bFGF; HBGF-2 [Similar Products]
 UniProt Entry Name    FGF2_HUMAN
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 NCBI Summary for BFGF 4    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BFGF 4    FGF2: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: Activator; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q26

Cellular Component: extracellular space; extracellular region; nucleus

Molecular Function: heparin binding; protein binding; growth factor activity; ligand-dependent nuclear receptor transcription coactivator activity; cytokine activity; chemoattractant activity; fibroblast growth factor receptor binding

Biological Process: extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; wound healing; activation of MAPK activity; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; chemotaxis; signal transduction; hyaluronan catabolic process; growth factor dependent regulation of satellite cell proliferation; positive regulation of MAP kinase activity; positive chemotaxis; positive regulation of cell proliferation; embryonic morphogenesis; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; nervous system development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of cell fate specification; positive regulation of blood vessel endothelial cell migration; positive regulation of phosphoinositide 3-kinase activity; negative regulation of blood vessel endothelial cell migration; regulation of angiogenesis; organ morphogenesis; positive regulation of angiogenesis; cell migration during sprouting angiogenesis; ureteric bud branching; release of sequestered calcium ion into cytosol; positive regulation of cell division; Ras protein signal transduction; phosphatidylinositol biosynthetic process; insulin receptor signaling pathway; innate immune response; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; inositol phosphate biosynthetic process
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 Research Articles on BFGF 4    1. Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with BFGF 4 elisa kitDiseases associated with BFGF 4 elisa kit
 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >185 publications with BFGF 4 and Kidney Diseases
Organs/Tissues associated with BFGF 4 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >4624 publications with BFGF 4 and Vascular
 Brain Antibodies  >2148 publications with BFGF 4 and Brain
 Bone Antibodies  >1766 publications with BFGF 4 and Bone
 Muscle Antibodies  >1764 publications with BFGF 4 and Muscle
 Embryonic Tissue Antibodies  >1256 publications with BFGF 4 and Embryonic Tissue
 Eye Antibodies  >1014 publications with BFGF 4 and Eye
 Skin Antibodies  >812 publications with BFGF 4 and Skin
 Connective Tissue Antibodies  >679 publications with BFGF 4 and Connective Tissue
 Heart Antibodies  >642 publications with BFGF 4 and Heart
 Bone Marrow Antibodies  >633 publications with BFGF 4 and Bone Marrow
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