NP_056363.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
860,662 Da
NCBI Official Full Name
bullous pemphigoid antigen 1 isoform 1eA
NCBI Official Synonym Full Names
dystonin
NCBI Official Synonym Symbols
DT; BPA; DMH; BP240; BPAG1; HSAN6; MACF2; CATX15; CATX-15; D6S1101 [Similar Products]
NCBI Protein Information
bullous pemphigoid antigen 1; trabeculin-beta; dystonia musculorum protein; hemidesmosomal plaque protein; bullous pemphigoid antigen 1, 230/240kDa
UniProt Protein Name
Dystonin
UniProt Synonym Protein Names
230 kDa bullous pemphigoid antigen; 230/240 kDa bullous pemphigoid antigen; Bullous pemphigoid antigen 1; BPA; Bullous pemphigoid antigen; Dystonia musculorum protein; Hemidesmosomal plaque protein
UniProt Synonym Gene Names
UniProt Entry Name
DYST_HUMAN
NCBI Summary for BP
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]
UniProt Comments for BP
BPAG1 iso3: a protein of the plakin family. Plakins are multi-domain proteins that have been shown to interact with microtubules, actin filaments and intermediate filaments, as well as proteins found in cellular junctions. Ten alternatively spliced human isoforms have been reported. BPAG1 has neuronal and muscle isoforms that consist of actin-binding and microtubule-binding domains at either end separated by a plakin domain and many spectrin repeats. Bpag1 isoforms with different N-termini may have differing roles. The plakin domain contains an apparent nuclear localization signal.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis; Microtubule-binding
Chromosomal Location of Human Ortholog: 6p12.1
Cellular Component: intermediate filament cytoskeleton; endoplasmic reticulum membrane; focal adhesion; cytoplasmic membrane-bound vesicle; leading edge; integral to membrane; intermediate filament; nuclear envelope; cell cortex; cytosol; Z disc; actin cytoskeleton; microtubule cytoskeleton; hemidesmosome; axon; cytoplasm; basal plasma membrane; basement membrane; nucleus
Molecular Function: integrin binding; protein C-terminus binding; microtubule plus-end binding; protein binding; protein homodimerization activity; calcium ion binding; actin binding
Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; hemidesmosome assembly; response to wounding; cell motility involved in cell locomotion; intermediate filament cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; microtubule cytoskeleton organization and biogenesis; cell cycle arrest; cell adhesion; maintenance of cell polarity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with BP elisa kit
Diseases associated with BP elisa kit
Organs/Tissues associated with BP elisa kit
|