NP_001007034.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,737 Da
NCBI Official Full Name
C-type lectin domain family 6 member A
NCBI Official Synonym Full Names
C-type lectin domain family 6, member A
NCBI Protein Information
C-type lectin domain family 6 member A; dectin 2; dectin-2; DC-associated C-type lectin 2; C-type lectin superfamily member 10; dendritic cell-associated C-type lectin 2; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10
UniProt Protein Name
C-type lectin domain family 6 member A
UniProt Synonym Protein Names
C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2
UniProt Synonym Gene Names
UniProt Entry Name
CLC6A_HUMAN
NCBI Summary for CLEC6A
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain (Kanazawa et al., 2004 [PubMed 15175046]).[supplied by OMIM, Nov 2010]
UniProt Comments for CLEC6A
dectin-2: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: integral to membrane
Molecular Function: carbohydrate binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; defense response to fungus; positive regulation of cytokine secretion
Research Articles on CLEC6A
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