NP_001272320.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,291 Da
NCBI Official Full Name
calcipressin-1 isoform e
NCBI Official Synonym Full Names
regulator of calcineurin 1
NCBI Official Synonym Symbols
CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78 [Similar Products]
NCBI Protein Information
calcipressin-1; near DSCR proline-rich protein; Down syndrome candidate region 1; calcium and oxidant-inducible mRNA; Down syndrome critical region gene 1; modulatory calcineurin-interacting protein 1; myocyte-enriched calcineurin-interacting protein 1
UniProt Protein Name
Calcipressin-1
UniProt Synonym Protein Names
Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1
UniProt Synonym Gene Names
UniProt Entry Name
RCAN1_HUMAN
NCBI Summary for RCAN1
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
UniProt Comments for RCAN1
RCAN1: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Interacts with RAF1. By calcium. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Belongs to the RCAN family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component: nucleus
Molecular Function: identical protein binding; protein binding; DNA binding; transcription factor activity
Biological Process: central nervous system development; regulation of transcription, DNA-dependent; blood circulation; calcium-mediated signaling; signal transduction
Research Articles on RCAN1
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Pathways associated with RCAN1 elisa kit
Diseases associated with RCAN1 elisa kit
Organs/Tissues associated with RCAN1 elisa kit
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