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CLCF1 elisa kit :: Rabbit Cardiotrophin Like Cytokine Factor 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS728227 CLCF1 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cardiotrophin Like Cytokine Factor 1 (CLCF1), ELISA Kit

 Also Known As   

Rabbit Cardiotrophin Like Cytokine Factor 1 ELISA Kit

 Product Gene Name   

CLCF1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 610313
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 Species Reactivity    Rabbit
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Sandwich
 Detection Range    25-500pg/mL
 Sensitivity    1.0pg/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CLCF1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CLCF1 purchase    MBS728227 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cardiotrophin Like Cytokine Factor 1 (CLCF1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 25-500pg/mL in biological research samples containing CLCF1, with an estimated sensitivity of 1.0pg/mL. The ELISA analytical biochemical technique of the MBS728227 kit is based on CLCF1 antibody-CLCF1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CLCF1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CLCF1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for CLCF1 elisa kit    Cardiovascular
NCBI/Uniprot data below describe general gene information for CLCF1. It may not necessarily be applicable to this product.
 NCBI GI #    261245022
 NCBI GeneID    23529
 NCBI Accession #    NP_001159684.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001166212.1 [Other Products]
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 UniProt Secondary Accession #    Q6NZA4; B4DNT4 [Other Products]
 UniProt Related Accession #    Q9UBD9 [Other Products]
 Molecular Weight    24,087 Da
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 NCBI Official Full Name    cardiotrophin-like cytokine factor 1 isoform 2
 NCBI Official Synonym Full Names    cardiotrophin-like cytokine factor 1
 NCBI Official Symbol    CLCF1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    cardiotrophin-like cytokine factor 1; novel neurotrophin-1; B-cell stimulating factor 3; B-cell stimulatory factor 3; B-cell-stimulating factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3
 UniProt Protein Name    Cardiotrophin-like cytokine factor 1
 UniProt Synonym Protein Names   
B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1
 Protein Family    Cardiotrophin-like cytokine factor
 UniProt Gene Name    CLCF1 [Similar Products]
 UniProt Synonym Gene Names    BSF3; CLC; NNT1; BSF-3; NNT-1 [Similar Products]
 UniProt Entry Name    CLCF1_HUMAN
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 NCBI Summary for CLCF1    This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
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 UniProt Comments for CLCF1    CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Apoptosis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: extracellular region

Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; cytokine activity; ciliary neurotrophic factor receptor binding; receptor binding

Biological Process: positive regulation of immunoglobulin production; cell surface receptor linked signal transduction; B cell differentiation; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; positive regulation of B cell proliferation; negative regulation of neuron apoptosis; JAK-STAT cascade; positive regulation of isotype switching to IgE isotypes; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of astrocyte differentiation

Disease: Cold-induced Sweating Syndrome 2
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 Research Articles on CLCF1    1. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CLCF1 elisa kitPathways associated with CLCF1 elisa kit
 Reference Product  PubMed Publications
 CRLF1 elisa kit  >9 publications with CLCF1 and CRLF1
 CNTFR elisa kit  >2 publications with CLCF1 and CNTFR
 PARK7 elisa kit  >1 publications with CLCF1 and PARK7
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with CLCF1 elisa kitOrgans/Tissues associated with CLCF1 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with CLCF1 and Nervous System Diseases
 Seizures Antibodies  >2 publications with CLCF1 and Seizures
 Cardiovascular Diseases Antibodies  >2 publications with CLCF1 and Cardiovascular Diseases
 Inflammation Antibodies  >2 publications with CLCF1 and Inflammation
 Lung Diseases Antibodies  >1 publications with CLCF1 and Lung Diseases
 Necrosis Antibodies  >1 publications with CLCF1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >5 publications with CLCF1 and Nerve
 Brain Antibodies  >3 publications with CLCF1 and Brain
 Skin Antibodies  >3 publications with CLCF1 and Skin
 Liver Antibodies  >1 publications with CLCF1 and Liver
 Bone Marrow Antibodies  >1 publications with CLCF1 and Bone Marrow
 Bone Antibodies  >1 publications with CLCF1 and Bone
 Lung Antibodies  >1 publications with CLCF1 and Lung
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