AAB97877.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,017 Da
NCBI Official Full Name
CD30L protein
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 8
NCBI Protein Information
tumor necrosis factor ligand superfamily member 8; CD30-L; CD30 ligand; CD153 antigen; CD30 antigen ligand
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 8
UniProt Synonym Protein Names
CD30 ligand
UniProt Synonym Gene Names
UniProt Entry Name
TNFL8_HUMAN
NCBI Summary for CD30L
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for CD30L
TNFSF8: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. Belongs to the tumor necrosis factor family.
Protein type: Apoptosis; Membrane protein, integral; Cytokine
Chromosomal Location of Human Ortholog: 9q33
Cellular Component: extracellular space; integral to plasma membrane
Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding
Biological Process: cell proliferation; defense response to Gram-positive bacterium; CD8-positive, alpha-beta T cell differentiation; cell-cell signaling; apoptosis; immune response; positive regulation of transcription from RNA polymerase II promoter; signal transduction
Research Articles on CD30L
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Products associated with CD30L elisa kit
Pathways associated with CD30L elisa kit
Diseases associated with CD30L elisa kit
Organs/Tissues associated with CD30L elisa kit
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