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COL7 elisa kit :: Rabbit Collagen Type VII ELISA Kit

Scan QR to view Datasheet Catalog #    MBS723636 COL7 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen Type VII (COL7), ELISA Kit

 Also Known As   

Rabbit Collagen Type VII ELISA Kit

 Product Gene Name   

COL7 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    607523
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 Species Reactivity    Rabbit
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Detection Range    1.0-25ng/mL
 Sensitivity    0.1ng/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of COL7 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for COL7 purchase    MBS723636 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Collagen Type VII (COL7) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.0-25ng/mL in biological research samples containing COL7, with an estimated sensitivity of 0.1ng/mL. The ELISA analytical biochemical technique of the MBS723636 kit is based on COL7 antibody-COL7 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COL7 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COL7. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for COL7 elisa kit    Cell Biology
NCBI/Uniprot data below describe general gene information for COL7. It may not necessarily be applicable to this product.
 NCBI GI #    4502961
 NCBI GeneID    1294
 NCBI Accession #    NP_000085.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000094.3 [Other Products]
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 UniProt Secondary Accession #    Q14054; Q16507 [Other Products]
 UniProt Related Accession #    Q02388 [Other Products]
 Molecular Weight    292,267 Da
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 NCBI Official Full Name    collagen alpha-1(VII) chain
 NCBI Official Synonym Full Names    collagen, type VII, alpha 1
 NCBI Official Symbol    COL7A1 [Similar Products]
 NCBI Official Synonym Symbols   
EBD1; EBR1; EBDCT
[Similar Products]
 NCBI Protein Information    collagen alpha-1(VII) chain; collagen alpha-1(VII) chain; LC collagen; long-chain collagen; collagen VII, alpha-1 polypeptide
 UniProt Protein Name    Collagen alpha-1(VII) chain
 UniProt Synonym Protein Names   
Long-chain collagen; LC collagen
 Protein Family    Zinc finger protein CONSTANS
 UniProt Gene Name    COL7A1 [Similar Products]
 UniProt Synonym Gene Names    LC collagen [Similar Products]
 UniProt Entry Name    CO7A1_HUMAN
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 NCBI Summary for COL7    This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]
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 UniProt Comments for COL7    COL7A1: the alpha chain of type VII collagen, an extra-cellular basement membrane protein restricted to the zone beneath stratified squamous epithelia. Type VII collagen fibrils are composed of three identical alpha collagen chains. Forms anchoring fibrils, which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. Dystrophic epidermolysis bullosa can result from defects in this protein or an autoimmune response made to type VII collagen. Homotrimer. Interacts with MIA3, facilitating its loading into transport carriers and subsequent secretion. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Extracellular matrix; Inhibitor

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: extracellular matrix; extracellular space; collagen type VII; endoplasmic reticulum lumen; extracellular region; basement membrane

Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; epidermis development; extracellular matrix organization and biogenesis; cell adhesion

Disease: Transient Bullous Dermolysis Of The Newborn; Epidermolysis Bullosa Dystrophica, Autosomal Dominant; Nail Disorder, Nonsyndromic Congenital, 8; Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Epidermolysis Bullosa Pruriginosa; Epidermolysis Bullosa Dystrophica, Pretibial; Epidermolysis Bullosa With Congenital Localized Absence Of Skin And Deformity Of Nails
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 Research Articles on COL7    1. Bullous dermolysis of the newborn (BDN) is a subtype of dystrophic epidermolysis bullosa caused by mutations in type VII collagen resulting in disorganized anchoring fibrils and sublamina densa blister formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with COL7 elisa kitPathways associated with COL7 elisa kit
 Reference Product  PubMed Publications
 COL1A1 elisa kit  >7 publications with COL7 and COL1A1
 COL17A1 elisa kit  >5 publications with COL7 and COL17A1
 COL6A1 elisa kit  >2 publications with COL7 and COL6A1
 COL6A3 elisa kit  >1 publications with COL7 and COL6A3
 ITGB1 elisa kit  >1 publications with COL7 and ITGB1
 COL18A1 elisa kit  >1 publications with COL7 and COL18A1
 COL4A1 elisa kit  >1 publications with COL7 and COL4A1
 Products by Pathway  Pathway Diagram
 Anchoring Fibril Formation Pathway antibodies  Anchoring Fibril Formation Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
Diseases associated with COL7 elisa kitOrgans/Tissues associated with COL7 elisa kit
 Disease Name  Pubmed Publications
 Epidermolysis Bullosa Dystrophica Antibodies  >243 publications with COL7 and Epidermolysis Bullosa Dystrophica
 Epidermolysis Bullosa Pruriginosa Antibodies  >30 publications with COL7 and Epidermolysis Bullosa Pruriginosa
 Pruritus Antibodies  >20 publications with COL7 and Pruritus
 Fibrosis Antibodies  >6 publications with COL7 and Fibrosis
 Inflammation Antibodies  >4 publications with COL7 and Inflammation
 Transient bullous dermolysis of the newborn Antibodies  >4 publications with COL7 and Transient bullous dermolysis of the newborn
 Nervous System Diseases Antibodies  >4 publications with COL7 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with COL7 and Cell Transformation, Neoplastic
 Brain Diseases Antibodies  >2 publications with COL7 and Brain Diseases
 Necrosis Antibodies  >2 publications with COL7 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >194 publications with COL7 and Skin
 Connective Tissue Antibodies  >10 publications with COL7 and Connective Tissue
 Mouth Antibodies  >7 publications with COL7 and Mouth
 Nerve Antibodies  >4 publications with COL7 and Nerve
 Uterus Antibodies  >2 publications with COL7 and Uterus
 Muscle Antibodies  >2 publications with COL7 and Muscle
 Embryonic Tissue Antibodies  >2 publications with COL7 and Embryonic Tissue
 Prostate Antibodies  >2 publications with COL7 and Prostate
 Brain Antibodies  >2 publications with COL7 and Brain
 Liver Antibodies  >1 publications with COL7 and Liver
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