CAB66087.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
2,706 Da
NCBI Official Full Name
complement component 9
NCBI Official Synonym Full Names
complement component 9
NCBI Protein Information
complement component C9
UniProt Protein Name
Complement component 9
UniProt Entry Name
Q9UGI4_HUMAN
NCBI Summary for C9
This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]
UniProt Comments for C9
C9: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. Defects in C9 are a cause of complement component 9 deficiency (C9D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Extracellular matrix; Membrane protein, multi-pass; Membrane protein, integral; Apoptosis
Chromosomal Location of Human Ortholog: 5p14-p12
Cellular Component: membrane attack complex; integral to plasma membrane; cytoplasm; plasma membrane; extracellular region
Biological Process: complement activation, alternative pathway; regulation of complement activation; innate immune response; hemolysis by symbiont of host red blood cells; complement activation, classical pathway
Disease: Macular Degeneration, Age-related, 15; Complement Component 9 Deficiency
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Pathways associated with C9 elisa kit
Organs/Tissues associated with C9 elisa kit
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