NP_001873.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,144 Da
NCBI Official Full Name
corticotropin-releasing factor-binding protein
NCBI Official Synonym Full Names
corticotropin releasing hormone binding protein
NCBI Protein Information
corticotropin-releasing factor-binding protein; CRH-BP; CRF-binding protein; corticotropin releasing hormone-binding protein; corticotropin-releasing hormone-binding protein
UniProt Protein Name
Corticotropin-releasing factor-binding protein
UniProt Synonym Protein Names
Corticotropin-releasing hormone-binding protein; CRH-BP
UniProt Synonym Gene Names
UniProt Entry Name
CRHBP_HUMAN
NCBI Summary for CRHBP
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
UniProt Comments for CRHBP
CRHBP: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.
Protein type: Secreted, signal peptide; Secreted; Inhibitor
Chromosomal Location of Human Ortholog: 5q13.3
Cellular Component: Golgi apparatus; multivesicular body; microtubule; extracellular space; endoplasmic reticulum; dendrite; perikaryon; intracellular; nerve terminal; nucleus; secretory granule
Molecular Function: protein binding; corticotropin-releasing hormone binding; peptide binding
Biological Process: negative regulation of adrenocorticotropic hormone secretion; regulated secretory pathway; synaptic transmission, dopaminergic; learning and/or memory; hormone-mediated signaling; cellular response to stress; regulation of adrenocorticotropin hormone secretion; hormone metabolic process; female pregnancy; behavioral response to ethanol; signal transduction; inflammatory response
Research Articles on CRHBP
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Products associated with CRHBP elisa kit
Pathways associated with CRHBP elisa kit
Diseases associated with CRHBP elisa kit
Organs/Tissues associated with CRHBP elisa kit
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