NP_001273059.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
139,179 Da
NCBI Official Full Name
cyclic nucleotide-gated cation channel beta-1 isoform c
NCBI Official Synonym Full Names
cyclic nucleotide gated channel beta 1
NCBI Official Synonym Symbols
CNG4; GAR1; GARP; RP45; CNCG2; CNCG4; GARP2; RCNC2; RCNCb; CNCG3L; CNGB1B; RCNCbeta [Similar Products]
NCBI Protein Information
cyclic nucleotide-gated cation channel beta-1; CNG-4; CNG channel beta-1; glutamic acid-rich protein; glutamic-acid-rich protein; cyclic nucleotide-gated channel beta-1; cyclic nucleotide-gated cation channel 4; cyclic nucleotide-gated cation channel gamma; cyclic nucleotide-gated cation channel modulatory subunit
UniProt Protein Name
Cyclic nucleotide-gated cation channel beta-1
UniProt Synonym Protein Names
Cyclic nucleotide-gated cation channel 4; CNG channel 4; CNG-4; CNG4; Cyclic nucleotide-gated cation channel gamma; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-1; CNG channel beta-1; Glutamic acid-rich protein; GARP
UniProt Synonym Gene Names
CNCG2; CNCG3L; CNCG4; RCNC2; CNG channel 4; CNG-4; CNG4; CNG channel beta-1; GARP [Similar Products]
UniProt Entry Name
CNGB1_HUMAN
NCBI Summary for CNGB1
In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
UniProt Comments for CNGB1
CNGB1: an integral membrane protein that forms a heterooligomeric complex with CNGA1. A modulatory subunit of cyclic nucleotide-gated cation channels.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16q13
Cellular Component: Golgi membrane; integral to plasma membrane; plasma membrane; terminal button; intracellular cyclic nucleotide activated cation channel complex
Molecular Function: voltage-gated potassium channel activity; protein binding; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; cGMP binding; cAMP binding; ligand-gated ion channel activity
Biological Process: phototransduction, visible light; cytosolic calcium ion homeostasis; organelle organization and biogenesis; photoreceptor cell maintenance; sensory perception of smell; rhodopsin mediated signaling; retinal homeostasis; regulation of membrane potential; regulation of rhodopsin mediated signaling; visual perception; protein localization in organelle; transport; detection of light stimulus involved in visual perception; protein heterotetramerization; cation transport
Disease: Retinitis Pigmentosa 45
Research Articles on CNGB1
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Products associated with CNGB1 elisa kit
Pathways associated with CNGB1 elisa kit
Diseases associated with CNGB1 elisa kit
Organs/Tissues associated with CNGB1 elisa kit
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