NP_006144.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,511 Da
NCBI Official Full Name
cytoplasmic protein NCK1 isoform 1
NCBI Official Synonym Full Names
NCK adaptor protein 1
NCBI Protein Information
cytoplasmic protein NCK1; NCK tyrosine kinase; melanoma NCK protein; SH2/SH3 adaptor protein NCK-alpha; non-catalytic region of tyrosine kinase
UniProt Protein Name
Cytoplasmic protein NCK1
UniProt Synonym Protein Names
NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alpha
UniProt Synonym Gene Names
UniProt Entry Name
NCK1_HUMAN
NCBI Summary for NCK1
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
UniProt Comments for NCK1
NCK1: adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q21
Cellular Component: endoplasmic reticulum; cytoplasm; plasma membrane; ribosome; intercellular junction; protein phosphatase type 1 complex; vesicle membrane; cytosol; nucleus
Molecular Function: protein binding, bridging; protein domain specific binding; protein binding; receptor signaling complex scaffold activity; SH3/SH2 adaptor activity; protein kinase inhibitor activity; cytoskeletal adaptor activity; receptor tyrosine kinase binding; receptor binding
Biological Process: lamellipodium biogenesis; axon guidance; positive regulation of translation in response to stress; T cell activation; negative regulation of peptidyl-serine phosphorylation; actin filament organization; signal complex assembly; response to other organism; substrate-bound cell migration, cell extension; T cell receptor signaling pathway; positive regulation of actin filament polymerization; negative regulation of protein kinase activity; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; vascular endothelial growth factor receptor signaling pathway
Research Articles on NCK1
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Products associated with NCK1 elisa kit
Pathways associated with NCK1 elisa kit
Diseases associated with NCK1 elisa kit
Organs/Tissues associated with NCK1 elisa kit
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