NP_001231812.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,755 Da
NCBI Official Full Name
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2
NCBI Official Synonym Full Names
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
NCBI Official Synonym Symbols
NCBI Protein Information
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; E2K; OGDC-E2
UniProt Protein Name
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
UniProt Synonym Protein Names
2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K
UniProt Synonym Gene Names
UniProt Entry Name
ODO2_HUMAN
NCBI Summary for DLST
This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for DLST
DLST: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Forms a 24-polypeptide structural core with octahedral symmetry. Belongs to the 2-oxoacid dehydrogenase family.
Protein type: Transferase; Amino Acid Metabolism - lysine degradation; Mitochondrial; Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.1.61
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: membrane; mitochondrial matrix; nucleus; oxoglutarate dehydrogenase complex
Molecular Function: dihydrolipoyllysine-residue succinyltransferase activity
Biological Process: cellular metabolic process; generation of precursor metabolites and energy; tricarboxylic acid cycle; L-lysine catabolic process to acetyl-CoA via saccharopine; lysine catabolic process
Research Articles on DLST
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Products associated with DLST elisa kit
Pathways associated with DLST elisa kit
Products by Pathway |
Pathway Diagram |
2-oxoglutarate Decarboxylation To Succinyl-CoA Pathway antibodies |
2-oxoglutarate Decarboxylation To Succinyl-CoA Pathway Diagram |
2-oxoglutarate Decarboxylation To Succinyl-CoA Pathway antibodies |
2-oxoglutarate Decarboxylation To Succinyl-CoA Pathway Diagram |
Carbon Metabolism Pathway antibodies |
Carbon Metabolism Pathway Diagram |
Carbon Metabolism Pathway antibodies |
Carbon Metabolism Pathway Diagram |
Citrate Cycle (TCA Cycle) Pathway antibodies |
Citrate Cycle (TCA Cycle) Pathway Diagram |
Citrate Cycle (TCA Cycle) Pathway antibodies |
Citrate Cycle (TCA Cycle) Pathway Diagram |
Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies |
Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram |
Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies |
Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram |
Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies |
Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram |
Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies |
Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram |
Diseases associated with DLST elisa kit
Organs/Tissues associated with DLST elisa kit
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