CAA84586.1
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
E-cadherin, partial
NCBI Official Synonym Full Names
cadherin 1
NCBI Official Synonym Symbols
UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324 [Similar Products]
NCBI Protein Information
cadherin-1
NCBI Summary for CDH1
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Research Articles on CDH1
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Products associated with CDH1 elisa kit
Pathways associated with CDH1 elisa kit
Diseases associated with CDH1 elisa kit
Organs/Tissues associated with CDH1 elisa kit
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