NP_114072.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
73,300 Da
NCBI Official Full Name
frizzled-8
NCBI Official Synonym Full Names
frizzled family receptor 8
NCBI Official Synonym Symbols
NCBI Protein Information
frizzled-8; frizzled homolog 8; frizzled 8, seven transmembrane spanning receptor
UniProt Protein Name
Frizzled-8
UniProt Synonym Gene Names
UniProt Entry Name
FZD8_HUMAN
NCBI Summary for FZD8
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for FZD8
FZD8: Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. Belongs to the G-protein coupled receptor Fz/Smo family.
Protein type: Membrane protein, multi-pass; GPCR, Fz/Smo family; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 10p11.21
Cellular Component: Golgi apparatus; plasma membrane; integral to membrane
Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; protein binding; Wnt receptor activity; ubiquitin protein ligase binding; PDZ domain binding; receptor binding
Biological Process: neuron differentiation; positive regulation of JNK activity; G-protein coupled receptor protein signaling pathway; T cell differentiation in the thymus; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin
Research Articles on FZD8
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Products associated with FZD8 elisa kit
Pathways associated with FZD8 elisa kit
Diseases associated with FZD8 elisa kit
Organs/Tissues associated with FZD8 elisa kit
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