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GRP78 elisa kit :: Rabbit Glucose Regulated Protein 78 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS016974 GRP78 elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glucose Regulated Protein 78 (GRP78), ELISA Kit

 Also Known As   

Rabbit Glucose Regulated Protein 78 ELISA Kit

 Product Gene Name   

GRP78 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 9; NC_000009.11 (127997127..128003666, complement). Location: 9q33.3
 OMIM    138120
 3D Structure    ModBase 3D Structure for P11021
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 Species Reactivity    Rabbit
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GRP78 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GRP78 purchase    MBS016974 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Glucose Regulated Protein 78 (GRP78) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GRP78. The ELISA analytical biochemical technique of the MBS016974 kit is based on GRP78 antibody-GRP78 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GRP78 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GRP78. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for GRP78. It may not necessarily be applicable to this product.
 NCBI GI #    386758
 NCBI GeneID    3309
 NCBI Accession #    AAA52614.1 [Other Products]
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 UniProt Primary Accession #    P11021 [Other Products]
 UniProt Secondary Accession #    Q2EF78; Q9NPF1; Q9UK02; B0QZ61 [Other Products]
 UniProt Related Accession #    P11021 [Other Products]
 Molecular Weight    72,333 Da
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 NCBI Official Full Name    GRP78, partial
 NCBI Official Synonym Full Names    heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
 NCBI Official Symbol    HSPA5 [Similar Products]
 NCBI Official Synonym Symbols   
BIP; MIF2; GRP78
[Similar Products]
 NCBI Protein Information    78 kDa glucose-regulated protein; immunoglobulin heavy chain-binding protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
 UniProt Protein Name    78 kDa glucose-regulated protein
 UniProt Synonym Protein Names   
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein
 Protein Family    78 kDa glucose-regulated protein
 UniProt Gene Name    HSPA5 [Similar Products]
 UniProt Synonym Gene Names    GRP78; GRP-78; BiP [Similar Products]
 UniProt Entry Name    GRP78_HUMAN
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 NCBI Summary for GRP78    The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]
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 UniProt Comments for GRP78    GRP78: a member of the HSP family of molecular chaperones required for endoplasmic reticulum integrity and stress-induced autophagy. Plays a central role in regulating the unfolded protein response (UPR), and is an obligatory component of autophagy in mammalian cells. May play an important role in cellular adaptation and oncogenic survival. One of the client proteins of GRP78 is protein double-stranded RNA-activated protein-like endoplasmic reticulum kinase (PERK). Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: signalosome; endoplasmic reticulum membrane; smooth endoplasmic reticulum; focal adhesion; cell surface; mitochondrion; endoplasmic reticulum lumen; endoplasmic reticulum; ER-Golgi intermediate compartment; membrane; plasma membrane; melanosome; integral to endoplasmic reticulum membrane; midbody; nucleus

Molecular Function: protein domain specific binding; protein binding; enzyme binding; chaperone binding; ubiquitin protein ligase binding; unfolded protein binding; ATPase activity; ribosome binding; calcium ion binding; misfolded protein binding; glycoprotein binding; ATP binding

Biological Process: platelet activation; ER-associated protein catabolic process; cerebellum structural organization; unfolded protein response; cerebellar Purkinje cell layer development; cellular response to glucose starvation; substantia nigra development; platelet degranulation; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; positive regulation of protein ubiquitination; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; ER overload response; positive regulation of cell migration; negative regulation of apoptosis
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 Research Articles on GRP78    1. BiP could upregulate mRNA transcription level and protein expression level of IRE1a.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GRP78 elisa kitPathways associated with GRP78 elisa kit
 Reference Product  PubMed Publications
 ATF6 elisa kit  >24 publications with GRP78 and ATF6
 ATF4 elisa kit  >21 publications with GRP78 and ATF4
 SIL1 elisa kit  >4 publications with GRP78 and SIL1
 ERN1 elisa kit  >4 publications with GRP78 and ERN1
 EIF2AK3 elisa kit  >2 publications with GRP78 and EIF2AK3
 NFYA elisa kit  >1 publications with GRP78 and NFYA
 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By ATF6-alpha Pathway antibodies  Activation Of Chaperone Genes By ATF6-alpha Pathway Diagram
 Activation Of Chaperones By ATF6-alpha Pathway antibodies  Activation Of Chaperones By ATF6-alpha Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with GRP78 elisa kitOrgans/Tissues associated with GRP78 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >49 publications with GRP78 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >47 publications with GRP78 and Nervous System Diseases
 Disease Models, Animal Antibodies  >44 publications with GRP78 and Disease Models, Animal
 Brain Diseases Antibodies  >40 publications with GRP78 and Brain Diseases
 Drug Toxicity Antibodies  >35 publications with GRP78 and Drug Toxicity
 Neoplasms Antibodies  >30 publications with GRP78 and Neoplasms
 Inflammation Antibodies  >20 publications with GRP78 and Inflammation
 Heart Diseases Antibodies  >18 publications with GRP78 and Heart Diseases
 Liver Diseases Antibodies  >16 publications with GRP78 and Liver Diseases
 Necrosis Antibodies  >15 publications with GRP78 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >63 publications with GRP78 and Brain
 Muscle Antibodies  >40 publications with GRP78 and Muscle
 Blood Antibodies  >32 publications with GRP78 and Blood
 Heart Antibodies  >31 publications with GRP78 and Heart
 Liver Antibodies  >29 publications with GRP78 and Liver
 Kidney Antibodies  >26 publications with GRP78 and Kidney
 Vascular Antibodies  >18 publications with GRP78 and Vascular
 Nerve Antibodies  >16 publications with GRP78 and Nerve
 Pancreas Antibodies  >13 publications with GRP78 and Pancreas
 Testis Antibodies  >11 publications with GRP78 and Testis
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