NP_001112362.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,776 Da
NCBI Official Full Name
glutaredoxin-1
NCBI Official Synonym Full Names
glutaredoxin (thioltransferase)
NCBI Official Synonym Symbols
NCBI Protein Information
glutaredoxin-1; TTase-1; thioltransferase-1
UniProt Protein Name
Glutaredoxin-1
UniProt Synonym Protein Names
Thioltransferase-1; TTase-1
UniProt Synonym Gene Names
UniProt Entry Name
GLRX1_HUMAN
NCBI Summary for GLRX
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
UniProt Comments for GLRX
GLRX1: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Belongs to the glutaredoxin family.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 5q14
Cellular Component: mitochondrion; cytosol; nucleus
Molecular Function: electron carrier activity; protein N-terminus binding; glutathione disulfide oxidoreductase activity
Biological Process: cell redox homeostasis; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; positive regulation of membrane potential
Research Articles on GLRX
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with GLRX elisa kit
Pathways associated with GLRX elisa kit
Diseases associated with GLRX elisa kit
Organs/Tissues associated with GLRX elisa kit
|