AAH72436.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,757 Da
NCBI Official Full Name
HYOU1 protein
NCBI Official Synonym Full Names
hypoxia up-regulated 1
NCBI Official Synonym Symbols
Grp170; HSP12A; ORP150; GRP-170; ORP-150 [Similar Products]
NCBI Protein Information
hypoxia up-regulated protein 1; 150 kDa oxygen-regulated protein; 170 kDa glucose-regulated protein; oxygen regulated protein (150kD)
UniProt Protein Name
Hypoxia up-regulated protein 1
UniProt Synonym Protein Names
150 kDa oxygen-regulated protein; ORP-150; 170 kDa glucose-regulated protein; GRP-170
UniProt Synonym Gene Names
UniProt Entry Name
HYOU1_HUMAN
NCBI Summary for HYOU1
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Comments for HYOU1
HYOU1: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. Belongs to the heat shock protein 70 family.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of Human Ortholog: 11q23.1-q23.3
Cellular Component: focal adhesion; smooth endoplasmic reticulum; membrane; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular region
Molecular Function: chaperone binding; ATP binding
Biological Process: receptor-mediated endocytosis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response
Research Articles on HYOU1
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Products associated with HYOU1 elisa kit
Pathways associated with HYOU1 elisa kit
Diseases associated with HYOU1 elisa kit
Organs/Tissues associated with HYOU1 elisa kit
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