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I-TAC elisa kit :: Rabbit I-TAC ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2507641 I-TAC elisa kit
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

I-TAC, ELISA Kit

 Also Known As   

Rabbit I-TAC (Interferon Inducible T-cell Alpha Chemoattractant) ELISA Kit

 Product Gene Name   

I-TAC elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    604852
 3D Structure    ModBase 3D Structure for O14625
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 Species Reactivity    Rabbit
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 Specificity    This kit recognizes natural and recombinant Rabbit I-TAC. No significant cross-reactivity or interference between Rabbit I-TAC and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    0.625-40ng/mL
 Sensitivity    0.375ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of I-TAC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for I-TAC purchase    MBS2507641 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the I-TAC, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625-40ng/mL in biological research samples containing I-TAC, with an estimated sensitivity of 0.375ng/mL. The ELISA analytical biochemical technique of the MBS2507641 kit is based on I-TAC antibody-I-TAC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect I-TAC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, I-TAC. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for I-TAC elisa kit

   Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Rabbit I-TAC concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to I-TAC. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for I-TAC and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain I-TAC, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of I-TAC. You can calculate the concentration of I-TAC in the samples by comparing the OD of the samples to the standard curve.
Sample Manual Insert of MBS2507641. Click to request current manual
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NCBI/Uniprot data below describe general gene information for I-TAC. It may not necessarily be applicable to this product.
 NCBI GI #    14030443
 NCBI GeneID    6373
 NCBI Accession #    AAK52900.1 [Other Products]
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 UniProt Primary Accession #    O14625 [Other Products]
 UniProt Secondary Accession #    Q53YA3; Q92840 [Other Products]
 UniProt Related Accession #    O14625 [Other Products]
 Molecular Weight    10,365 Da
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 NCBI Official Full Name    I-TAC, partial
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 11
 NCBI Official Symbol    CXCL11 [Similar Products]
 NCBI Official Synonym Symbols   
IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 11; beta-R1; interferon gamma-inducible protein 9; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine B11; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member 9B; small-inducible cytokine B11
 UniProt Protein Name    C-X-C motif chemokine 11
 UniProt Synonym Protein Names   
Beta-R1; H174; Interferon gamma-inducible protein 9; IP-9; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11
 UniProt Gene Name    CXCL11 [Similar Products]
 UniProt Synonym Gene Names    ITAC; SCYB11; SCYB9B; IP-9; I-TAC [Similar Products]
 UniProt Entry Name    CXL11_HUMAN
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 NCBI Summary for I-TAC    Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
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 UniProt Comments for I-TAC    CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q21.2

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; immune response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP metabolic process; chemotaxis; signal transduction; inflammatory response; regulation of cell proliferation
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 Research Articles on I-TAC    1. Although TARC and I-TAC may not directly regulate pruritus in atopic dermatitis patients, these chemokines are very sensitive disease markers of AD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with I-TAC elisa kitPathways associated with I-TAC elisa kit
 Reference Product  PubMed Publications
 CXCL10 elisa kit  >456 publications with I-TAC and CXCL10
 CXCL9 elisa kit  >361 publications with I-TAC and CXCL9
 CXCR3 elisa kit  >304 publications with I-TAC and CXCR3
 CCL5 elisa kit  >87 publications with I-TAC and CCL5
 CXCR7 elisa kit  >40 publications with I-TAC and CXCR7
 CCR5 elisa kit  >37 publications with I-TAC and CCR5
 CXCL13 elisa kit  >14 publications with I-TAC and CXCL13
 CXCL6 elisa kit  >10 publications with I-TAC and CXCL6
 CCR3 elisa kit  >10 publications with I-TAC and CCR3
 PF4 elisa kit  >6 publications with I-TAC and PF4
 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
Diseases associated with I-TAC elisa kitOrgans/Tissues associated with I-TAC elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >186 publications with I-TAC and Inflammation
 Necrosis Antibodies  >80 publications with I-TAC and Necrosis
 Lung Diseases Antibodies  >61 publications with I-TAC and Lung Diseases
 Disease Models, Animal Antibodies  >55 publications with I-TAC and Disease Models, Animal
 Liver Diseases Antibodies  >35 publications with I-TAC and Liver Diseases
 Cardiovascular Diseases Antibodies  >30 publications with I-TAC and Cardiovascular Diseases
 Fibrosis Antibodies  >28 publications with I-TAC and Fibrosis
 Death Antibodies  >22 publications with I-TAC and Death
 Kidney Diseases Antibodies  >22 publications with I-TAC and Kidney Diseases
 Adenocarcinoma Antibodies  >19 publications with I-TAC and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >83 publications with I-TAC and Lung
 Vascular Antibodies  >77 publications with I-TAC and Vascular
 Skin Antibodies  >51 publications with I-TAC and Skin
 Liver Antibodies  >44 publications with I-TAC and Liver
 Muscle Antibodies  >29 publications with I-TAC and Muscle
 Intestine Antibodies  >27 publications with I-TAC and Intestine
 Bone Marrow Antibodies  >22 publications with I-TAC and Bone Marrow
 Mouth Antibodies  >13 publications with I-TAC and Mouth
 Uterus Antibodies  >9 publications with I-TAC and Uterus
 Connective Tissue Antibodies  >4 publications with I-TAC and Connective Tissue
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