AAK52900.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,365 Da
NCBI Official Full Name
I-TAC, partial
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 11
NCBI Official Synonym Symbols
IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B [Similar Products]
NCBI Protein Information
C-X-C motif chemokine 11; beta-R1; interferon gamma-inducible protein 9; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine B11; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member 9B; small-inducible cytokine B11
UniProt Protein Name
C-X-C motif chemokine 11
UniProt Synonym Protein Names
Beta-R1; H174; Interferon gamma-inducible protein 9; IP-9; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11
UniProt Synonym Gene Names
UniProt Entry Name
CXL11_HUMAN
NCBI Summary for I-TAC
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
UniProt Comments for I-TAC
CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family.
Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 4q21.2
Cellular Component: extracellular space; extracellular region
Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity
Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; immune response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP metabolic process; chemotaxis; signal transduction; inflammatory response; regulation of cell proliferation
Research Articles on I-TAC
Precautions
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Pathways associated with I-TAC elisa kit
Diseases associated with I-TAC elisa kit
Organs/Tissues associated with I-TAC elisa kit
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