NP_001252516.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,872 Da
NCBI Official Full Name
insulin-like 3 isoform 1
NCBI Official Synonym Full Names
insulin-like 3 (Leydig cell)
NCBI Protein Information
insulin-like 3; leydig insulin -like hormone; leydig insulin-like peptide; prepro-INSL3; relaxin-like factor b
UniProt Protein Name
Insulin-like 3
UniProt Synonym Protein Names
Leydig insulin-like peptide; Ley-I-L; Relaxin-like factorCleaved into the following 2 chains:Insulin-like 3 B chain; Insulin-like 3 A chain
UniProt Synonym Gene Names
UniProt Entry Name
INSL3_HUMAN
NCBI Summary for INSL3
This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
UniProt Comments for INSL3
INSL3: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO); also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low. Belongs to the insulin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19p13.2-p12
Cellular Component: extracellular space; perinuclear region of cytoplasm; extracellular region
Molecular Function: G-protein-coupled receptor binding; protease binding; hormone activity; insulin receptor binding; receptor binding
Biological Process: negative regulation of cell proliferation; cell-cell signaling; in utero embryonic development; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; male gonad development; spermatogenesis; G-protein signaling, adenylate cyclase inhibiting pathway; oocyte maturation; negative regulation of apoptosis
Disease: Cryptorchidism, Unilateral Or Bilateral
Research Articles on INSL3
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Products associated with INSL3 elisa kit
Pathways associated with INSL3 elisa kit
Diseases associated with INSL3 elisa kit
Organs/Tissues associated with INSL3 elisa kit
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