NP_000868.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,402 Da
NCBI Official Full Name
interleukin-1 receptor type 1 isoform 1
NCBI Official Synonym Full Names
interleukin 1 receptor, type I
NCBI Official Synonym Symbols
P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha [Similar Products]
NCBI Protein Information
interleukin-1 receptor type 1; IL-1R-1; IL-1RT1; IL-1RT-1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor alpha, type I
UniProt Protein Name
Interleukin-1 receptor type 1
UniProt Synonym Protein Names
CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD_antigen: CD121aCleaved into the following 2 chains:Interleukin-1 receptor type 1, membrane form; mIL-1R1; mIL-1RI; Interleukin-1 receptor type 1, soluble form; sIL-1R1; sIL-1RI
UniProt Synonym Gene Names
IL1R; IL1RA; IL1RT1; IL-1R-1; IL-1RT-1; IL-1RT1; IL-1R-alpha; mIL-1R1; mIL-1RI; sIL-1R1; sIL-1RI [Similar Products]
UniProt Entry Name
IL1R1_HUMAN
NCBI Summary for IL-1R1
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
UniProt Comments for IL-1R1
IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family.
Protein type: Membrane protein, integral; Receptor, cytokine; EC 2.7.11.25
Chromosomal Location of Human Ortholog: 2q12
Cellular Component: cell surface; membrane; integral to plasma membrane; extracellular region; plasma membrane
Molecular Function: interleukin-1, Type I, activating receptor activity; signal transducer activity; protein binding; transmembrane receptor activity; protease binding; platelet-derived growth factor receptor binding; interleukin-1 receptor activity
Biological Process: cell surface receptor linked signal transduction; regulation of inflammatory response; immune response
Research Articles on IL-1R1
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Products associated with IL-1R1 elisa kit
Pathways associated with IL-1R1 elisa kit
Diseases associated with IL-1R1 elisa kit
Organs/Tissues associated with IL-1R1 elisa kit
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