AAC23650.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,042 Da
NCBI Official Full Name
leptin receptor
NCBI Official Synonym Full Names
leptin receptor
NCBI Protein Information
leptin receptor; huB219; OB receptor
UniProt Protein Name
Leptin receptor
UniProt Synonym Protein Names
HuB219; OB receptor; OB-R; CD_antigen: CD295
UniProt Synonym Gene Names
UniProt Entry Name
LEPR_HUMAN
NCBI Summary for LR/Ob-R
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
UniProt Comments for LR/Ob-R
LEPR: the receptor for leptin (obesity factor). A single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Five alternatively spliced transcript variants have been reported.
Protein type: Receptor, cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p31
Cellular Component: extracellular region; plasma membrane; integral to membrane; receptor complex
Molecular Function: identical protein binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; transmembrane receptor activity
Biological Process: cholesterol metabolic process; cell surface receptor linked signal transduction; negative regulation of hydrolase activity; cytokine and chemokine mediated signaling pathway; multicellular organismal development; negative regulation of gluconeogenesis; energy reserve metabolic process
Disease: Leptin Receptor Deficiency
Research Articles on LR/Ob-R
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with LR/Ob-R elisa kit
Pathways associated with LR/Ob-R elisa kit
Diseases associated with LR/Ob-R elisa kit
Organs/Tissues associated with LR/Ob-R elisa kit
|