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PRNP elisa kit :: Rabbit Major prion protein (PRNP) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7239031 PRNP elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Major prion protein (PRNP), ELISA Kit

 Also Known As   

Rabbit Major prion protein (PRNP) ELISA Kit

 Product Gene Name   

PRNP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    606688
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 Species Reactivity    Rabbit
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PRNP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PRNP purchase    MBS7239031 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Major prion protein (PRNP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PRNP. The ELISA analytical biochemical technique of the MBS7239031 kit is based on PRNP antibody-PRNP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PRNP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PRNP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for PRNP elisa kit    Neurobiology
NCBI/Uniprot data below describe general gene information for PRNP. It may not necessarily be applicable to this product.
 NCBI GI #    34335270
 NCBI GeneID    5621
 NCBI Accession #    NP_898902.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_183079.2 [Other Products]
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 UniProt Secondary Accession #    O60489; P78446; Q15216; Q15221; Q27H91; Q5QPB4; Q8TBG0; Q96E70; Q9UP19 [Other Products]
 UniProt Related Accession #    P04156; F7VJQ1 [Other Products]
 Molecular Weight    8,691 Da
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 NCBI Official Full Name    major prion protein preproprotein
 NCBI Official Synonym Full Names    prion protein
 NCBI Official Symbol    PRNP [Similar Products]
 NCBI Official Synonym Symbols   
CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C
[Similar Products]
 NCBI Protein Information    alternative prion protein; major prion protein; CD230 antigen; prion-related protein
 UniProt Protein Name    Major prion protein
 UniProt Synonym Protein Names   
ASCR; PrP27-30; PrP33-35C; CD_antigen: CD230
 Protein Family    Major prion protein
 UniProt Gene Name    PRNP [Similar Products]
 UniProt Synonym Gene Names    ALTPRP; PRIP; PRP; PrP [Similar Products]
 UniProt Entry Name    PRIO_HUMAN
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 NCBI Summary for PRNP    The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
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 UniProt Comments for PRNP    PRNP: May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains. PrP is found in high quantity in the brain of humans and animals infected with neurodegenerative diseases known as transmissible spongiform encephalopathies or prion diseases, like: Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI), Gerstmann-Straussler disease (GSD), Huntington disease-like type 1 (HDL1) and kuru in humans; scrapie in sheep and goat; bovine spongiform encephalopathy (BSE) in cattle; transmissible mink encephalopathy (TME); chronic wasting disease (CWD) of mule deer and elk; feline spongiform encephalopathy (FSE) in cats and exotic ungulate encephalopathy (EUE) in nyala and greater kudu. The prion diseases illustrate three manifestations of CNS degeneration: (1) infectious (2) sporadic and (3) dominantly inherited forms. TME, CWD, BSE, FSE, EUE are all thought to occur after consumption of prion-infected foodstuffs. Defects in PRNP are the cause of Creutzfeldt-Jakob disease (CJD). CJD occurs primarily as a sporadic disorder (1 per million), while 10-15% are familial. Accidental transmission of CJD to humans appears to be iatrogenic (contaminated human growth hormone (HGH), corneal transplantation, electroencephalographic electrode implantation, etc.). Epidemiologic studies have failed to implicate the ingestion of infected annimal meat in the pathogenesis of CJD in human. The triad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration of neurons, (2) severe astrocytic gliosis that often appears to be out of proportion to the degree of nerve cell loss, and (3) amyloid plaque formation. CJD is characterized by progressive dementia and myoclonic seizures, affecting adults in mid-life. Some patients present sleep disorders, abnormalities of high cortical function, cerebellar and corticospinal disturbances. The disease ends in death after a 3-12 months illness. Defects in PRNP are the cause of fatal familial insomnia (FFI). FFI is an autosomal dominant disorder and is characterized by neuronal degeneration limited to selected thalamic nuclei and progressive insomnia. Defects in PRNP are the cause of Gerstmann-Straussler disease (GSD). GSD is a heterogeneous disorder and was defined as a spinocerebellar ataxia with dementia and plaquelike deposits. GSD incidence is less than 2 per 100 million live births. Defects in PRNP are the cause of Huntington disease-like type 1 (HDL1). HDL1 is an autosomal dominant, early onset neurodegenerative disorder with prominent psychiatric features. Defects in PRNP are the cause of kuru (KURU). Kuru is transmitted during ritualistic cannibalism, among natives of the New Guinea highlands. Patients exhibit various movement disorders like cerebellar abnormalities, rigidity of the limbs, and clonus. Emotional lability is present, and dementia is conspicuously absent. Death usually occurs from 3 to 12 month after onset. Defects in PRNP are the cause of spongiform encephalopathy with neuropsychiatric features (SENF); an autosomal dominant presenile dementia with a rapidly progressive and protracted clinical course. The dementia was characterized clinically by frontotemporal features, including early personality changes. Some patients had memory loss, several showed aggressiveness, hyperorality and verbal stereotypy, others had parkinsonian symptoms. Belongs to the prion family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Membrane protein, GPI anchor; Microtubule-binding

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: Golgi apparatus; mitochondrial outer membrane; cell surface; extrinsic to membrane; endoplasmic reticulum; cytoplasm; plasma membrane; integral to membrane; nucleus; lipid raft

Molecular Function: tubulin binding; identical protein binding; ATP-dependent protein binding; protein binding; copper ion binding; chaperone binding; microtubule binding

Biological Process: axon guidance; cellular copper ion homeostasis; metabolic process; negative regulation of transcription factor activity; negative regulation of activated T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of interleukin-2 production; response to cadmium ion; regulation of protein localization; learning and/or memory; negative regulation of interleukin-17 production; negative regulation of protein amino acid phosphorylation; negative regulation of interferon-gamma production; response to oxidative stress; cell cycle arrest; protein homooligomerization; negative regulation of apoptosis

Disease: Gerstmann-straussler Disease; Huntington Disease-like 1; Kuru, Susceptibility To; Fatal Familial Insomnia; Spongiform Encephalopathy With Neuropsychiatric Features; Creutzfeldt-jakob Disease
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 Research Articles on PRNP    1. findings show the PrP GPI-anchor signal peptide (SP) undergoes degradation via the proteasome; P238S point mutation partially protects the PrP GPI-anchor SP from degradation; data provide attempt to address the fate of a GPI-anchor SP and identify a role for the P238 mutation, suggesting PrP GPI-anchor SP could play a role in neurodegenerative prion diseases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PRNP elisa kitDiseases associated with PRNP elisa kit
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 NCAM1 Interactions Pathway antibodies  NCAM1 Interactions Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Disease Name  Pubmed Publications
 Prion Diseases Antibodies  >1012 publications with PRNP and Prion Diseases
 Nervous System Diseases Antibodies  >1001 publications with PRNP and Nervous System Diseases
 Creutzfeldt-Jakob Syndrome Antibodies  >376 publications with PRNP and Creutzfeldt-Jakob Syndrome
 Scrapie Antibodies  >256 publications with PRNP and Scrapie
 Gerstmann-Straussler-Scheinker Disease Antibodies  >115 publications with PRNP and Gerstmann-Straussler-Scheinker Disease
 Alzheimer Disease Antibodies  >109 publications with PRNP and Alzheimer Disease
 Insomnia, Fatal Familial Antibodies  >97 publications with PRNP and Insomnia, Fatal Familial
 Disease Models, Animal Antibodies  >70 publications with PRNP and Disease Models, Animal
 Nerve Degeneration Antibodies  >27 publications with PRNP and Nerve Degeneration
 Inflammation Antibodies  >15 publications with PRNP and Inflammation
Organs/Tissues associated with PRNP elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >577 publications with PRNP and Brain
 Blood Antibodies  >116 publications with PRNP and Blood
 Nerve Antibodies  >93 publications with PRNP and Nerve
 Ganglia Antibodies  >32 publications with PRNP and Ganglia
 Muscle Antibodies  >21 publications with PRNP and Muscle
 Lymph Node Antibodies  >20 publications with PRNP and Lymph Node
 Testis Antibodies  >18 publications with PRNP and Testis
 Bone Antibodies  >17 publications with PRNP and Bone
 Heart Antibodies  >17 publications with PRNP and Heart
 Intestine Antibodies  >17 publications with PRNP and Intestine
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