NP_663469.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,799 Da
NCBI Official Full Name
NAD-dependent malic enzyme, mitochondrial
NCBI Official Synonym Full Names
malic enzyme 2, NAD(+)-dependent, mitochondrial
NCBI Official Synonym Symbols
NAD-ME; AW120568; D030040L20Rik [Similar Products]
NCBI Protein Information
NAD-dependent malic enzyme, mitochondrial
UniProt Protein Name
NAD-dependent malic enzyme, mitochondrial
UniProt Synonym Protein Names
Malic enzyme 2
UniProt Synonym Gene Names
UniProt Comments for ME2
ME2: a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]
Protein type: Carbohydrate Metabolism - pyruvate; EC 1.1.1.38; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 18|18 E2
Cellular Component: mitochondrion
Molecular Function: catalytic activity; malate dehydrogenase (decarboxylating) activity; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity; malic enzyme activity; metal ion binding; NAD binding; oxaloacetate decarboxylase activity; oxidoreductase activity
Biological Process: malate metabolic process; metabolic process; pyruvate metabolic process; regulation of NADP metabolic process
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Pathways associated with ME2 elisa kit
Diseases associated with ME2 elisa kit
Organs/Tissues associated with ME2 elisa kit
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