NP_006409.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,280 Da
NCBI Official Full Name
olfactomedin-4
NCBI Official Synonym Full Names
olfactomedin 4
NCBI Official Synonym Symbols
GC1; OLM4; OlfD; GW112; hGC-1; hOLfD; UNQ362; bA209J19.1 [Similar Products]
NCBI Protein Information
olfactomedin-4; antiapoptotic protein GW112; G-CSF-stimulated clone 1 protein
UniProt Protein Name
Olfactomedin-4
UniProt Synonym Protein Names
Antiapoptotic protein GW112; G-CSF-stimulated clone 1 protein; hGC-1; hOLfD
UniProt Synonym Gene Names
UniProt Entry Name
OLFM4_HUMAN
NCBI Summary for OLFM4
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
UniProt Comments for OLFM4
OLFM4: May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 13q14.3
Cellular Component: extracellular space; specific granule; azurophil granule; mitochondrion; perinuclear region of cytoplasm; plasma membrane; secretory granule
Molecular Function: protein homodimerization activity; cadherin binding; catalytic activity
Biological Process: regulation of apoptosis; metabolic process; negative regulation of immune response; negative regulation of I-kappaB kinase/NF-kappaB cascade; regulation of phagocytosis; cell adhesion; protein homooligomerization
Research Articles on OLFM4
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Products associated with OLFM4 elisa kit
Diseases associated with OLFM4 elisa kit
Organs/Tissues associated with OLFM4 elisa kit
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