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PAR1 elisa kit :: Rabbit Protease Activated Receptor 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS746436
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protease Activated Receptor 1 (PAR1), ELISA Kit

 Also Known As   

Rabbit Protease Activated Receptor 1 ELISA Kit

 Product Gene Name   

PAR1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 OMIM    187930
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 Species Reactivity    Rabbit
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Sensitivity    0.1 ng/mL.
 Intended Uses    This PAR-1 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Rabbit PAR-1. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of PAR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PAR1 purchase    MBS746436 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Protease Activated Receptor 1 (PAR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PAR1, with an estimated sensitivity of 0.1 ng/mL. The ELISA analytical biochemical technique of the MBS746436 kit is based on PAR1 antibody-PAR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PAR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PAR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for PAR1 elisa kit    Signal Transduction
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 Typical Testing Data/Standard Curve (for reference only) of PAR1 elisa kit    PAR1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS746436
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NCBI/Uniprot data below describe general gene information for PAR1. It may not necessarily be applicable to this product.
 NCBI GI #    166362740
 NCBI GeneID    2149
 NCBI Accession #    NP_001983.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001992.3 [Other Products]
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 UniProt Secondary Accession #    Q53XV0; Q96RF7; Q9BUN4 [Other Products]
 UniProt Related Accession #    P25116 [Other Products]
 Molecular Weight    47,441 Da
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 NCBI Official Full Name    proteinase-activated receptor 1
 NCBI Official Synonym Full Names    coagulation factor II (thrombin) receptor
 NCBI Official Symbol    F2R [Similar Products]
 NCBI Official Synonym Symbols   
TR; HTR; CF2R; PAR1; PAR-1
[Similar Products]
 NCBI Protein Information    proteinase-activated receptor 1; protease-activated receptor 1
 UniProt Protein Name    Proteinase-activated receptor 1
 UniProt Synonym Protein Names   
Coagulation factor II receptor; Thrombin receptor
 Protein Family    Transcription factor
 UniProt Gene Name    F2R [Similar Products]
 UniProt Synonym Gene Names    CF2R; PAR1; TR; PAR-1 [Similar Products]
 UniProt Entry Name    PAR1_HUMAN
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 NCBI Summary for PAR1    Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PAR1    PAR1: a G-protein coupled high-affinity receptor for activated thrombin or trypsin. Coupled to G proteins that stimulate phosphoinositide hydrolysis. Coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelet activation and in vascular development.

Protein type: Cell development/differentiation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: Golgi apparatus; postsynaptic membrane; integral to plasma membrane; early endosome; plasma membrane; extracellular region; caveola; neuromuscular junction

Molecular Function: G-protein coupled receptor activity; protein binding; G-protein beta-subunit binding; G-protein alpha-subunit binding; receptor binding; thrombin receptor activity

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of blood coagulation; activation of MAPKK activity; negative regulation of glomerular filtration; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; positive regulation of caspase activity; positive regulation of JAK-STAT cascade; response to lipopolysaccharide; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; connective tissue replacement during inflammatory response; positive regulation of MAPKKK cascade; platelet dense granule organization and biogenesis; regulation of interleukin-1 beta production; positive regulation of cell proliferation; protein kinase C activation; response to wounding; negative regulation of neuron apoptosis; positive regulation of smooth muscle contraction; inflammatory response; establishment of synaptic specificity at neuromuscular junction; STAT protein nuclear translocation; caspase activation; platelet activation; anatomical structure morphogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of Rho protein signal transduction; positive regulation of phosphoinositide 3-kinase cascade; G-protein coupled receptor protein signaling pathway; tyrosine phosphorylation of STAT protein; homeostasis of number of cells within a tissue; release of sequestered calcium ion into cytosol; regulation of blood coagulation; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of release of sequestered calcium ion into cytosol; regulation of sensory perception of pain; positive regulation of calcium ion transport; blood coagulation; positive regulation of cell migration
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 Research Articles on PAR1    1. our observations show that PAR1 and PAR2 act as a functional unit in tumor development and placenta-uterus interactions. This conclusion may have significant consequences on future breast cancer therapeutic modalities and improved late pregnancy outcome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PAR1 elisa kitPathways associated with PAR1 elisa kit
 Reference Product  PubMed Publications
 GNA15 elisa kit  >1 publications with PAR1 and GNA15
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with PAR1 elisa kitOrgans/Tissues associated with PAR1 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >5 publications with PAR1 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >5 publications with PAR1 and Vascular Diseases
 Heart Diseases Antibodies  >4 publications with PAR1 and Heart Diseases
 Stomach Neoplasms Antibodies  >4 publications with PAR1 and Stomach Neoplasms
 Inflammation Antibodies  >4 publications with PAR1 and Inflammation
 Thrombosis Antibodies  >3 publications with PAR1 and Thrombosis
 Necrosis Antibodies  >2 publications with PAR1 and Necrosis
 Carcinoma Antibodies  >2 publications with PAR1 and Carcinoma
 Skin Diseases Antibodies  >2 publications with PAR1 and Skin Diseases
 Hypertension Antibodies  >2 publications with PAR1 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >6 publications with PAR1 and Vascular
 Heart Antibodies  >6 publications with PAR1 and Heart
 Brain Antibodies  >5 publications with PAR1 and Brain
 Stomach Antibodies  >4 publications with PAR1 and Stomach
 Muscle Antibodies  >3 publications with PAR1 and Muscle
 Uterus Antibodies  >2 publications with PAR1 and Uterus
 Skin Antibodies  >2 publications with PAR1 and Skin
 Lung Antibodies  >2 publications with PAR1 and Lung
 Prostate Antibodies  >1 publications with PAR1 and Prostate
 Intestine Antibodies  >1 publications with PAR1 and Intestine
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