NP_003721.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,481 Da
NCBI Official Full Name
ribonuclease T2
NCBI Official Synonym Full Names
ribonuclease T2
NCBI Official Synonym Symbols
RNASE6PL; bA514O12.3; RP11-514O12.3 [Similar Products]
NCBI Protein Information
ribonuclease T2; ribonuclease 6
UniProt Protein Name
Ribonuclease T2
UniProt Synonym Protein Names
Ribonuclease 6
UniProt Synonym Gene Names
UniProt Entry Name
RNT2_HUMAN
NCBI Summary for RNASET2
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]
UniProt Comments for RNASET2
RNASET2: Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM). An infantile- onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. Belongs to the RNase T2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ribonuclease; Secreted, signal peptide; EC 3.1.27.-; RNA-binding; Secreted
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: lysosomal lumen; extracellular space; endoplasmic reticulum lumen; lysosome; extracellular region
Molecular Function: ribonuclease T2 activity; RNA binding; ribonuclease activity
Biological Process: RNA catabolic process
Disease: Leukoencephalopathy, Cystic, Without Megalencephaly
Research Articles on RNASET2
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Products associated with RNASET2 elisa kit
Diseases associated with RNASET2 elisa kit
Organs/Tissues associated with RNASET2 elisa kit
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