NP_001257620.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,819 Da
NCBI Official Full Name
spermine oxidase isoform 6
NCBI Official Synonym Full Names
spermine oxidase
NCBI Official Synonym Symbols
PAO; SMO; PAO1; PAOH; PAO-1; PAOH1; C20orf16 [Similar Products]
NCBI Protein Information
spermine oxidase; polyamine oxidase 1; flavin containing amine oxidase; flavin-containing spermine oxidase; putative cyclin G1 interacting protein
UniProt Protein Name
Spermine oxidase
UniProt Synonym Protein Names
Polyamine oxidase 1
UniProt Synonym Gene Names
UniProt Entry Name
SMOX_HUMAN
NCBI Summary for SM
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]
UniProt Comments for SM
SMOX: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. Belongs to the flavin monoamine oxidase family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.5.3.16; Oxidoreductase
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: polyamine oxidase activity
Biological Process: spermine catabolic process; polyamine biosynthetic process; xenobiotic metabolic process; polyamine catabolic process; polyamine metabolic process
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Pathways associated with SM elisa kit
Diseases associated with SM elisa kit
Organs/Tissues associated with SM elisa kit
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