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TGM2 elisa kit :: Rabbit TGM2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2506706
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGM2, ELISA Kit

★Popular Item★
 Also Known As   

Rabbit TGM2 (Transglutaminase 2, Tissue) ELISA Kit

 Product Gene Name   

TGM2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2506706 COA    COA PDF
 OMIM    190196
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 Species Reactivity    Rabbit
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 Specificity    This kit recognizes natural and some recombinant Rabbit TGM2. No significant crossreactivity or interference between Rabbit TGM2 and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    1.563-100ng/mL
 Sensitivity    Min: 0.938ng/mL; Max: 100ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TGM2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TGM2 purchase    MBS2506706 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the TGM2, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.563-100ng/mL in biological research samples containing TGM2, with an estimated sensitivity of Min: 0.938ng/mL; Max: 100ng/mL. The ELISA analytical biochemical technique of the MBS2506706 kit is based on TGM2 antibody-TGM2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TGM2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TGM2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TGM2 elisa kit

   Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Rabbit TGM2 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA method. The micro ELISA plate provided in this kit has been pre-coated with antibodies specific to Rabbit TGM2. Standards or samples added to appropriate micro ELISA plate wells will bind to the antibodies. Biotinylated detection antibodies specific to Rabbit TGM2 and Avidin-Horseradish Peroxidase (HRP) conjugate can then be added successively to each micro plate well. After incubation, free components are washed away. When the substrate solution is added to each well, only those wells that contain Rabbit TGM2, biotinylated detection antibody and Avidin-HRP complex will appear blue in color. The enzyme-substrate reaction will be terminated and appears yellow color by adding sulphuric acid solution. The optical density (OD) can be measured with spectrophotometry at a wavelength of 450 nm 2 nm. The OD value is proportional to the concentration of Rabbit TGM2. You can calculate the concentration of Rabbit TGM2 in samples by comparing the OD of the samples with the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of TGM2 elisa kit    TGM2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2506706. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TGM2. It may not necessarily be applicable to this product.
 NCBI GI #    49522843
 NCBI GeneID    7052
 NCBI Accession #    AAH73946.1 [Other Products]
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 UniProt Secondary Accession #    Q16436; Q6B838; Q9BTN7; Q9UH35; E1P5V9 [Other Products]
 UniProt Related Accession #    P21980 [Other Products]
 Molecular Weight    38,671 Da
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 NCBI Official Full Name    TGM2 protein, partial
 NCBI Official Synonym Full Names    transglutaminase 2
 NCBI Official Symbol    TGM2 [Similar Products]
 NCBI Official Synonym Symbols   
TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h
[Similar Products]
 NCBI Protein Information    protein-glutamine gamma-glutamyltransferase 2; C polypeptide, protein-glutamine-gamma-glutamyltransferase; TG(C); TGase C; TGase H; TGase-2; TGase-H; epididymis secretory protein Li 45; tissue transglutaminase; transglutaminase C; transglutaminase H; transglutaminase-2
 UniProt Protein Name    Protein-glutamine gamma-glutamyltransferase 2
 UniProt Synonym Protein Names   
Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2
 Protein Family    Protein-glutamine gamma-glutamyltransferase
 UniProt Gene Name    TGM2 [Similar Products]
 UniProt Synonym Gene Names    TG(C); TGC; TGase C; TGase H; TGase-2 [Similar Products]
 UniProt Entry Name    TGM2_HUMAN
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 NCBI Summary for TGM2    Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TGM2    TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described.

Protein type: EC 2.3.2.13; Transferase

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: focal adhesion; mitochondrion; plasma membrane; cytosol

Molecular Function: protein domain specific binding; protein binding; GTP binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cell adhesion; positive regulation of apoptosis; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of smooth muscle cell proliferation; blood vessel remodeling; apoptotic cell clearance; protein homooligomerization; elevation of mitochondrial calcium ion concentration; positive regulation of inflammatory response
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 Research Articles on TGM2    1. define a role for TG2 activity at the surface of human macrophages in multiple stages of AC clearance and we propose that TG2, in association with heparan sulphates, may exert its effect on AC clearance via a mechanism involving the crosslinking of CD44
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TGM2 elisa kitPathways associated with TGM2 elisa kit
 Reference Product  PubMed Publications
 ITGB1 elisa kit  >1 publications with TGM2 and ITGB1
 FN1 elisa kit  >1 publications with TGM2 and FN1
 Products by Pathway  Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Thromboxane A2 Receptor Signaling Pathway antibodies  Thromboxane A2 Receptor Signaling Pathway Diagram
Diseases associated with TGM2 elisa kitOrgans/Tissues associated with TGM2 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with TGM2 and Inflammation
 Necrosis Antibodies  >6 publications with TGM2 and Necrosis
 Disease Models, Animal Antibodies  >6 publications with TGM2 and Disease Models, Animal
 Lung Neoplasms Antibodies  >6 publications with TGM2 and Lung Neoplasms
 Fibrosis Antibodies  >5 publications with TGM2 and Fibrosis
 Cardiovascular Diseases Antibodies  >5 publications with TGM2 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >5 publications with TGM2 and Breast Neoplasms
 Brain Neoplasms Antibodies  >4 publications with TGM2 and Brain Neoplasms
 Kidney Diseases Antibodies  >4 publications with TGM2 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with TGM2 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >11 publications with TGM2 and Lung
 Brain Antibodies  >10 publications with TGM2 and Brain
 Liver Antibodies  >9 publications with TGM2 and Liver
 Blood Antibodies  >9 publications with TGM2 and Blood
 Eye Antibodies  >7 publications with TGM2 and Eye
 Bone Antibodies  >7 publications with TGM2 and Bone
 Skin Antibodies  >7 publications with TGM2 and Skin
 Connective Tissue Antibodies  >5 publications with TGM2 and Connective Tissue
 Vascular Antibodies  >5 publications with TGM2 and Vascular
 Muscle Antibodies  >5 publications with TGM2 and Muscle
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