NP_003344.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,458 Da
NCBI Official Full Name
urocortin preproprotein
NCBI Official Synonym Full Names
urocortin
NCBI Official Synonym Symbols
NCBI Protein Information
urocortin; prepro-urocortin; urocortin, preproprotein
UniProt Protein Name
Urocortin
UniProt Entry Name
UCN1_HUMAN
NCBI Summary for UCN2
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
UniProt Comments for UCN2
UCN: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: dendrite; extracellular region; perikaryon; nerve terminal
Molecular Function: corticotropin-releasing hormone receptor 1 binding; histone deacetylase inhibitor activity; neuropeptide hormone activity; protein binding; corticotropin-releasing hormone receptor 2 binding
Biological Process: regulation of synaptic transmission, glutamatergic; positive regulation of translation; negative regulation of hormone secretion; response to glucocorticoid stimulus; positive regulation of collagen biosynthetic process; drinking behavior; response to pain; negative regulation of cell size; female pregnancy; positive regulation of vasodilation; pancreatic juice secretion; negative regulation of appetite; response to estradiol stimulus; positive regulation of adrenocorticotropic hormone secretion; sensory perception of sound; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; negative regulation of blood pressure; inflammatory response; neurite development; associative learning; negative regulation of histone deacetylation; activation of protein kinase A; positive regulation of interleukin-6 production; social behavior; positive regulation of cell growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of vascular permeability; G-protein coupled receptor protein signaling pathway; aerobic respiration; response to oxidative stress; positive regulation of DNA replication; negative regulation of apoptosis
Research Articles on UCN2
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Products associated with UCN2 elisa kit
Diseases associated with UCN2 elisa kit
Organs/Tissues associated with UCN2 elisa kit
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