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ACh elisa kit :: Rabbit acetylcholine (ACh) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2601759 ACh elisa kit
Unit / Price
48-Strip-Wells  /  $315 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

acetylcholine (ACh), ELISA Kit

 Also Known As   

Rabbit acetylcholine (ACh) ELISA Kit

 Product Gene Name   

ACh elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    608930
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 Species Reactivity    Rabbit
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACh elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ACh purchase    MBS2601759 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the acetylcholine (ACh) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACh. The ELISA analytical biochemical technique of the MBS2601759 kit is based on ACh antibody-ACh antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACh antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACh. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ACh. It may not necessarily be applicable to this product.
 NCBI GI #    87567783
 NCBI GeneID    1134
 NCBI Accession #    NP_001034612.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001039523.2 [Other Products]
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 UniProt Secondary Accession #    B4DRV6; D3DPE8 [Other Products]
 UniProt Related Accession #    P02708 [Other Products]
 Molecular Weight    51,839 Da
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 NCBI Official Full Name    acetylcholine receptor subunit alpha isoform a
 NCBI Official Synonym Full Names    cholinergic receptor, nicotinic, alpha 1 (muscle)
 NCBI Official Symbol    CHRNA1 [Similar Products]
 NCBI Official Synonym Symbols   
ACHRA; ACHRD; CHRNA; CMS2A; FCCMS; SCCMS
[Similar Products]
 NCBI Protein Information    acetylcholine receptor subunit alpha; nicotinic cholinergic receptor alpha 1; muscle nicotinic acetylcholine receptor; nicotinic acetylcholine receptor alpha subunit; acetylcholine receptor, nicotinic, alpha 1 (muscle); cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
 UniProt Protein Name    Acetylcholine receptor subunit alpha
 UniProt Gene Name    CHRNA1 [Similar Products]
 UniProt Synonym Gene Names    ACHRA; CHNRA [Similar Products]
 UniProt Entry Name    ACHA_HUMAN
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 NCBI Summary for ACh    The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012]
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 UniProt Comments for ACh    nAChRA1: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNA1 are a cause of multiple pterygium syndrome lethal type (MUPSL). Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent. The alpha subunit is the main focus for antibody binding in myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs. Defects in CHRNA1 are a cause of congenital myasthenic syndrome slow-channel type (SCCMS). SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes. Defects in CHRNA1 are a cause of congenital myasthenic syndrome fast-channel type (FCCMS). FCCMS is a congenital myasthenic syndrome characterized by kinetic abnormalities of the AChR. In most cases, FCCMS is due to mutations that decrease activity of the AChR by slowing the rate of opening of the receptor channel, speeding the rate of closure of the channel, or decreasing the number of openings of the channel during ACh occupancy. The result is failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 1/CHRNA1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, ligand-gated; Channel, cation; Membrane protein, integral; Receptor, misc.; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; cell surface; plasma membrane; cell junction; neuromuscular junction

Molecular Function: acetylcholine receptor activity; ion channel activity; acetylcholine binding; nicotinic acetylcholine-activated cation-selective channel activity

Biological Process: skeletal muscle contraction; muscle maintenance; synaptic transmission; regulation of membrane potential; transport; neuromuscular process; generation of action potential; neuromuscular synaptic transmission; skeletal muscle growth; musculoskeletal movement; signal transduction; neuromuscular junction development

Disease: Myasthenic Syndrome, Congenital, Fast-channel; Myasthenic Syndrome, Congenital, Slow-channel; Multiple Pterygium Syndrome, Lethal Type
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 Research Articles on ACh    1. HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACh elisa kitPathways associated with ACh elisa kit
 Reference Product  PubMed Publications
 CHRND elisa kit  >10 publications with ACh and CHRND
 RAPSN elisa kit  >9 publications with ACh and RAPSN
 CHRNG elisa kit  >8 publications with ACh and CHRNG
 CHRNE elisa kit  >5 publications with ACh and CHRNE
 AIRE elisa kit  >4 publications with ACh and AIRE
 NEB elisa kit  >1 publications with ACh and NEB
 IRF8 elisa kit  >1 publications with ACh and IRF8
 MAPK1 elisa kit  >1 publications with ACh and MAPK1
 Products by Pathway  Pathway Diagram
 Acetylcholine Binding And Downstream Events Pathway antibodies  Acetylcholine Binding And Downstream Events Pathway Diagram
 Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies  Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
 Effects Of Botulinum Toxin Pathway antibodies  Effects Of Botulinum Toxin Pathway Diagram
 ErbB2/ErbB3 Signaling Events Pathway antibodies  ErbB2/ErbB3 Signaling Events Pathway Diagram
 Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
Diseases associated with ACh elisa kitOrgans/Tissues associated with ACh elisa kit
 Disease Name  Pubmed Publications
 MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE Antibodies  >5 publications with ACh and MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE
 Cardiovascular Diseases Antibodies  >3 publications with ACh and Cardiovascular Diseases
 Inflammation Antibodies  >3 publications with ACh and Inflammation
 Edema Antibodies  >3 publications with ACh and Edema
 Myasthenic Syndrome, Congenital, Fast-Channel Antibodies  >2 publications with ACh and Myasthenic Syndrome, Congenital, Fast-Channel
 Disease Models, Animal Antibodies  >2 publications with ACh and Disease Models, Animal
 Heart Diseases Antibodies  >1 publications with ACh and Heart Diseases
 Atherosclerosis Antibodies  >1 publications with ACh and Atherosclerosis
 Necrosis Antibodies  >1 publications with ACh and Necrosis
 Hyperplasia Antibodies  >1 publications with ACh and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >26 publications with ACh and Muscle
 Thymus Antibodies  >5 publications with ACh and Thymus
 Brain Antibodies  >3 publications with ACh and Brain
 Skin Antibodies  >2 publications with ACh and Skin
 Heart Antibodies  >1 publications with ACh and Heart
 Vascular Antibodies  >1 publications with ACh and Vascular
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