NP_001136036.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,900 Da
NCBI Official Full Name
cGMP-gated cation channel alpha-1 isoform 1
NCBI Official Synonym Full Names
cyclic nucleotide gated channel alpha 1
NCBI Official Synonym Symbols
CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha [Similar Products]
NCBI Protein Information
cGMP-gated cation channel alpha-1; CNG channel alpha-1; interleukin-1 homologue; cyclic nucleotide-gated channel alpha-1; cyclic nucleotide-gated cation channel 1; cyclic nucleotide-gated channel, photoreceptor; rod photoreceptor cGMP-gated channel subunit alpha
UniProt Protein Name
cGMP-gated cation channel alpha-1
UniProt Synonym Protein Names
Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
UniProt Synonym Gene Names
UniProt Entry Name
CNGA1_HUMAN
NCBI Summary for CNGA1
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
UniProt Comments for CNGA1
CNGA1: a cyclic nucleotide-gated cation channel of rod cells in the retina. Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. Activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. CNG ion channels exist in the retinal, olfactory and cochlear sensory neurons.
Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4p12
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: voltage-gated potassium channel activity; protein binding; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; cGMP binding
Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of membrane potential; regulation of rhodopsin mediated signaling; visual perception; transport
Disease: Retinitis Pigmentosa 49; Retinitis Pigmentosa
Research Articles on CNGA1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with CNGA1 elisa kit
Pathways associated with CNGA1 elisa kit
Diseases associated with CNGA1 elisa kit
Organs/Tissues associated with CNGA1 elisa kit
|