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CBS elisa kit :: Rabbit cystathionine beta-synthase (CBS) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7222658 CBS elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

cystathionine beta-synthase (CBS), ELISA Kit

 Also Known As   

Rabbit cystathionine beta-synthase (CBS) ELISA Kit

 Product Synonym Names    Rabbit cystathionine b-synthase (CBS) ELISA Kit
 Product Gene Name   

CBS elisa kit

[Similar Products]
 Product Synonym Gene Name    CBS [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    613381
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 Species Reactivity    Rabbit
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of CBS elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CBS purchase    MBS7222658 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the cystathionine beta-synthase (CBS) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CBS. The ELISA analytical biochemical technique of the MBS7222658 kit is based on CBS antibody-CBS antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CBS antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CBS. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for CBS elisa kit    Cell Biology
NCBI/Uniprot data below describe general gene information for CBS. It may not necessarily be applicable to this product.
 NCBI GI #    543959
 NCBI GeneID    875
 NCBI Accession #    P35520.2 [Other Products]
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 UniProt Secondary Accession #    Q99425; Q9BWC5; B2R993; D3DSK4 [Other Products]
 UniProt Related Accession #    P35520 [Other Products]
 Molecular Weight    61,863 Da
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 NCBI Official Full Name    Cystathionine beta-synthase
 NCBI Official Synonym Full Names    cystathionine-beta-synthase
 NCBI Official Symbol    CBS [Similar Products]
 NCBI Official Synonym Symbols   
HIP4
[Similar Products]
 NCBI Protein Information    cystathionine beta-synthase; beta-thionase; serine sulfhydrase; methylcysteine synthase
 UniProt Protein Name    Cystathionine beta-synthase
 UniProt Synonym Protein Names   
Beta-thionase; Serine sulfhydrase
 Protein Family    Cystathionine beta-synthase
 UniProt Gene Name    CBS [Similar Products]
 UniProt Entry Name    CBS_HUMAN
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 NCBI Summary for CBS    The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2010]
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 UniProt Comments for CBS    CBS: Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury. Defects in CBS are the cause of cystathionine beta- synthase deficiency (CBSD). CBSD is an enzymatic deficiency resulting in altered sulfur metabolism and homocystinuria. The clinical features of untreated homocystinuria due to CBS deficiency include myopia, ectopia lentis, mental retardation, skeletal anomalies resembling Marfan syndrome, and thromboembolic events. Light skin and hair can also be present. Biochemical features include increased urinary homocystine and methionine. Belongs to the cysteine synthase/cystathionine beta- synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 4.2.1.22; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine; Lyase; Amino Acid Metabolism - glycine, serine and threonine

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus; cytosol

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; enzyme binding; cystathionine beta-synthase activity; metal ion binding; ubiquitin protein ligase binding; heme binding; pyridoxal phosphate binding

Biological Process: cysteine biosynthetic process via cystathionine; homocysteine catabolic process; sulfur amino acid metabolic process; L-serine metabolic process; transsulfuration; cysteine biosynthetic process from serine; homocysteine metabolic process; L-serine catabolic process; L-cysteine catabolic process

Disease: Homocystinuria Due To Cystathionine Beta-synthase Deficiency
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 Research Articles on CBS    1. Human cystathionine ss-synthase (CBS) is identified as a new player in nitrite reduction with implications for the nitrite-dependent control of HS production.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CBS elisa kitPathways associated with CBS elisa kit
 Reference Product  PubMed Publications
 MTR elisa kit  >76 publications with CBS and MTR
 BHMT elisa kit  >37 publications with CBS and BHMT
 SHMT1 elisa kit  >20 publications with CBS and SHMT1
 CTH elisa kit  >15 publications with CBS and CTH
 AHCY elisa kit  >7 publications with CBS and AHCY
 HTT elisa kit  >1 publications with CBS and HTT
 SHMT2 elisa kit  >1 publications with CBS and SHMT2
 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway antibodies  Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway Diagram
 Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway antibodies  Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway Diagram
 Cysteine Formation From Homocysteine Pathway antibodies  Cysteine Formation From Homocysteine Pathway Diagram
 Folate-Alcohol And Cancer Pathway antibodies  Folate-Alcohol And Cancer Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
Diseases associated with CBS elisa kitOrgans/Tissues associated with CBS elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >695 publications with CBS and Nervous System Diseases
 Brain Diseases Antibodies  >471 publications with CBS and Brain Diseases
 Hyperhomocysteinemia Antibodies  >345 publications with CBS and Hyperhomocysteinemia
 Cardiovascular Diseases Antibodies  >337 publications with CBS and Cardiovascular Diseases
 Homocystinuria Antibodies  >182 publications with CBS and Homocystinuria
 Malnutrition Antibodies  >163 publications with CBS and Malnutrition
 Inflammation Antibodies  >101 publications with CBS and Inflammation
 Congenital Abnormalities Antibodies  >89 publications with CBS and Congenital Abnormalities
 Hypertension Antibodies  >65 publications with CBS and Hypertension
 Liver Diseases Antibodies  >64 publications with CBS and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >928 publications with CBS and Brain
 Blood Antibodies  >704 publications with CBS and Blood
 Vascular Antibodies  >290 publications with CBS and Vascular
 Liver Antibodies  >229 publications with CBS and Liver
 Nerve Antibodies  >178 publications with CBS and Nerve
 Muscle Antibodies  >175 publications with CBS and Muscle
 Eye Antibodies  >115 publications with CBS and Eye
 Kidney Antibodies  >103 publications with CBS and Kidney
 Ganglia Antibodies  >90 publications with CBS and Ganglia
 Lung Antibodies  >89 publications with CBS and Lung
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