NP_001076179.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
95,306 Da
NCBI Official Full Name
protein argonaute-2
NCBI Official Synonym Symbols
NCBI Protein Information
protein argonaute-2; eIF2C 2; eIF-2C 2; argonaute2; protein slicer; translation initiation factor eIF2C; Eukaryotic translation initiation factor 2C 2; eukaryotic translation initiation factor 2C, 2
UniProt Protein Name
Protein argonaute-2
UniProt Synonym Protein Names
Argonaute RISC catalytic component 2; Eukaryotic translation initiation factor 2C 2; eIF-2C 2; eIF2C 2; Protein slicer
UniProt Synonym Gene Names
UniProt Entry Name
AGO2_RABIT
UniProt Comments for EIF2C2
Function: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions UniRule annotationHAMAP-Rule:MF_03031
Catalytic activity: Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationHAMAP-Rule:MF_03031
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Diseases associated with EIF2C2 elisa kit
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