NP_786938.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
96,622 Da
NCBI Official Full Name
low-density lipoprotein receptor
NCBI Official Synonym Full Names
low density lipoprotein receptor
NCBI Official Synonym Symbols
NCBI Protein Information
low-density lipoprotein receptor; LDL receptor
UniProt Protein Name
Low-density lipoprotein receptor
UniProt Synonym Gene Names
UniProt Entry Name
LDLR_RAT
UniProt Comments for LSP
LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.; Cell surface
Cellular Component: Golgi apparatus; cell surface; recycling endosome membrane; lysosome; early endosome; integral to membrane; coated pit; caveola; membrane; late endosome; plasma membrane; endosome; receptor complex; external side of plasma membrane
Molecular Function: low-density lipoprotein receptor activity; very-low-density lipoprotein receptor activity; protein binding; low-density lipoprotein binding; calcium ion binding; glycoprotein binding
Biological Process: cholesterol metabolic process; receptor-mediated endocytosis; lipoprotein catabolic process; cholesterol transport; response to glucagon stimulus; cholesterol absorption; response to hormone stimulus; lipoprotein metabolic process; endocytosis; lipid transport; response to estradiol stimulus; cholesterol homeostasis; response to estrogen stimulus; response to hypoxia; phospholipid transport; lipid metabolic process; aging
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Products associated with LSP elisa kit
Pathways associated with LSP elisa kit
Diseases associated with LSP elisa kit
Organs/Tissues associated with LSP elisa kit
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