NP_001164546.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,692 Da
NCBI Official Full Name
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
NCBI Protein Information
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; PP2A subunit B isoform alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform B55-alpha; PP2A, subunit B, B-alpha isoform; PP2A subunit B isoform PR55-alpha; PP2A, subunit B, R2-alpha isoform; PP2A, subunit B, B55-alpha isoform; PP2A, subunit B, PR55-alpha isoform; protein phosphatase 2A1 B alpha subunit
UniProt Protein Name
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
UniProt Synonym Protein Names
PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha
UniProt Entry Name
2ABA_RABIT
UniProt Comments for PPP2R2A
PPP2R2A: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53. Expressed in all tissues examined. Belongs to the phosphatase 2A regulatory subunit B family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component: nucleoplasm; protein phosphatase type 2A complex; cytosol
Molecular Function: protein binding; protein phosphatase type 2A regulator activity; protein serine/threonine phosphatase activity
Biological Process: mitotic nuclear envelope reassembly; regulation of catalytic activity; mRNA catabolic process, nonsense-mediated decay; response to morphine; gene expression; mitotic cell cycle; protein amino acid dephosphorylation; G2/M transition of mitotic cell cycle; signal transduction
Research Articles on PPP2R2A
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Organs/Tissues associated with PPP2R2A elisa kit
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