NP_001009493.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
126,205 Da
NCBI Official Full Name
2'-5'-oligoadenylate synthase 3
NCBI Official Synonym Full Names
2'-5'-oligoadenylate synthetase 3
NCBI Protein Information
2'-5'-oligoadenylate synthase 3
UniProt Protein Name
2'-5'-oligoadenylate synthase 3
UniProt Synonym Gene Names
UniProt Entry Name
OAS3_RAT
UniProt Comments for Oas3
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L ().
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Pathways associated with Oas3 elisa kit
Diseases associated with Oas3 elisa kit
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