NP_112343.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,609 Da
NCBI Official Full Name
3-phosphoinositide-dependent protein kinase 1
NCBI Official Synonym Full Names
3-phosphoinositide dependent protein kinase-1
NCBI Protein Information
3-phosphoinositide-dependent protein kinase 1; pkB kinase; protein kinase B kinase
UniProt Protein Name
3-phosphoinositide-dependent protein kinase 1
UniProt Synonym Protein Names
Protein kinase B kinase
UniProt Synonym Gene Names
UniProt Entry Name
PDPK1_RAT
NCBI Summary for PDPK1
may catalyze the phosphorylation and activation of protein kinase B [RGD, Feb 2006]
UniProt Comments for PDPK1
PDK1: an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described.
Protein type: Nuclear receptor co-regulator; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.1; AGC group; PKB family
Cellular Component: focal adhesion; cell projection; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; phospholipase binding; 3-phosphoinositide-dependent protein kinase activity; kinase activity; protein kinase binding; ATP binding; insulin receptor binding; phospholipase activator activity
Biological Process: focal adhesion formation; epidermal growth factor receptor signaling pathway; regulation of mast cell degranulation; cell migration; transcription, DNA-dependent; activation of protein kinase B; peptidyl-threonine phosphorylation; calcium-mediated signaling; protein amino acid phosphorylation; hyperosmotic response; cellular response to insulin stimulus; regulation of transcription, DNA-dependent; negative regulation of toll-like receptor signaling pathway; negative regulation of protein kinase activity; positive regulation of release of sequestered calcium ion into cytosol; regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transforming growth factor beta receptor signaling pathway
Research Articles on PDPK1
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Pathways associated with PDPK1 elisa kit
Diseases associated with PDPK1 elisa kit
Organs/Tissues associated with PDPK1 elisa kit
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