JAN85363.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
93,254 Da
NCBI Official Full Name
6-phosphofructokinase, muscle type
UniProt Protein Name
ATP-dependent 6-phosphofructokinase, muscle type
UniProt Synonym Protein Names
6-phosphofructokinase type A; Phosphofructo-1-kinase isozyme A; PFK-A; Phosphohexokinase
UniProt Synonym Gene Names
UniProt Entry Name
PFKAM_HUMAN
UniProt Comments for Pfkm
PFKM: phosphofructokinase, muscle type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts. Defects in PFKM are the cause of glycogen storage disease VII (GSD-VII) also known as Tarui disease. Two alternatively spliced isoforms have been described.
Protein type: Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.1.11; Carbohydrate Metabolism - fructose and mannose; Kinase, other
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: 6-phosphofructokinase complex; apical plasma membrane; cytosol
Molecular Function: 6-phosphofructokinase activity; ATP binding; identical protein binding; kinase binding; metal ion binding; protein binding; protein C-terminus binding; protein homodimerization activity
Biological Process: carbohydrate metabolic process; carbohydrate phosphorylation; fructose 6-phosphate metabolic process; glucose homeostasis; glucose metabolic process; glycogen catabolic process; glycolysis; muscle maintenance; positive regulation of insulin secretion; protein oligomerization
Disease: Glycogen Storage Disease Vii
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Diseases associated with Pfkm elisa kit
Organs/Tissues associated with Pfkm elisa kit
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