NP_001186731.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,124 Da
NCBI Official Full Name
60S ribosomal protein L11 isoform 2
NCBI Official Synonym Full Names
ribosomal protein L11
NCBI Protein Information
60S ribosomal protein L11; CLL-associated antigen KW-12; cell growth-inhibiting protein 34
UniProt Protein Name
60S ribosomal protein L11
UniProt Synonym Protein Names
CLL-associated antigen KW-12
UniProt Entry Name
RL11_HUMAN
NCBI Summary for RPL11
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]
UniProt Comments for RPL11
RPL11: Binds to 5S ribosomal RNA. Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML. Defects in RPL11 are the cause of Diamond-Blackfan anemia type 7 (DBA7). DBA7 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein L5P family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ribosomal; Nucleolus; Motility/polarity/chemotaxis; Translation
Chromosomal Location of Human Ortholog: 1p36.1-p35
Cellular Component: membrane; cytoplasm; nucleolus; cytosol
Molecular Function: rRNA binding; protein binding; structural constituent of ribosome; RNA binding
Biological Process: SRP-dependent cotranslational protein targeting to membrane; translation; viral reproduction; ribosomal large subunit biogenesis and assembly; translational termination; viral infectious cycle; cellular protein metabolic process; translational elongation; translational initiation; mRNA catabolic process, nonsense-mediated decay; viral transcription; gene expression; rRNA processing; protein targeting
Disease: Diamond-blackfan Anemia 7
Research Articles on RPL11
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Products associated with RPL11 elisa kit
Pathways associated with RPL11 elisa kit
Diseases associated with RPL11 elisa kit
Organs/Tissues associated with RPL11 elisa kit
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