NP_067087.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
12,554 Da
NCBI Official Full Name
60S ribosomal protein L35a
NCBI Official Synonym Full Names
ribosomal protein L35a
NCBI Protein Information
60S ribosomal protein L35a
UniProt Protein Name
60S ribosomal protein L35a
NCBI Summary for RPL35A
ribosomal protein that binds tRNA [RGD, Feb 2006]
UniProt Comments for RPL35A
RPL35A: Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site. Defects in RPL35A are the cause of Diamond-Blackfan anemia type 5 (DBA5). DBA5 is a form of Diamond- Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein L35Ae family.
Protein type: RNA-binding; Ribosomal; Translation
Chromosomal Location of Human Ortholog: 12p11
Molecular Function: structural constituent of ribosome; tRNA binding
Biological Process: ribosomal large subunit biogenesis
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Pathways associated with RPL35A elisa kit
Diseases associated with RPL35A elisa kit
Organs/Tissues associated with RPL35A elisa kit
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