NP_001245300.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
103,241 Da
NCBI Official Full Name
alpha-actinin-3 isoform 2
NCBI Official Synonym Full Names
actinin, alpha 3
NCBI Protein Information
alpha-actinin-3; F-actin cross-linking protein; alpha-actinin skeletal muscle
UniProt Protein Name
Alpha-actinin-3
UniProt Synonym Protein Names
Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein
UniProt Entry Name
ACTN3_HUMAN
NCBI Summary for ACTN3
This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants. The reference genome contains the non-coding allele. The non-functional allele of this gene is associated with elite athlete status. [provided by RefSeq, Apr 2012]
UniProt Comments for ACTN3
ACTN3: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Belongs to the alpha-actinin family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: focal adhesion; actin filament; pseudopodium; cytosol
Molecular Function: integrin binding; protein binding; protein homodimerization activity; structural constituent of muscle; calcium ion binding; actin binding
Biological Process: regulation of apoptosis; focal adhesion formation; muscle filament sliding
Research Articles on ACTN3
Precautions
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Pathways associated with ACTN3 elisa kit
Diseases associated with ACTN3 elisa kit
Organs/Tissues associated with ACTN3 elisa kit
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