EAW91465.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,348 Da
NCBI Official Full Name
adenosine A1 receptor
NCBI Official Synonym Full Names
adenosine A1 receptor
NCBI Official Synonym Symbols
NCBI Protein Information
adenosine receptor A1
UniProt Protein Name
Adenosine receptor A1
UniProt Entry Name
AA1R_HUMAN
NCBI Summary for ADORA1
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ADORA1
ADORA1: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Endoplasmic reticulum; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: asymmetric synapse; axolemma; basolateral plasma membrane; cell soma; dendritic spine; endoplasmic reticulum; integral to plasma membrane; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; presynaptic membrane; terminal button
Molecular Function: adenosine receptor activity, G-protein coupled; G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; heat shock protein binding; heterotrimeric G-protein binding; phospholipase C activity; protein binding; protein heterodimerization activity; purine nucleoside binding
Biological Process: activation of MAPKK activity; adenosine receptor signaling pathway; cell-cell signaling; cognition; detection of temperature stimulus involved in sensory perception of pain; G-protein signaling, adenylate cyclase inhibiting pathway; inflammatory response; lipid catabolic process; negative regulation of acute inflammatory response; negative regulation of apoptosis; negative regulation of blood pressure; negative regulation of cell proliferation; negative regulation of circadian sleep/wake cycle, non-REM sleep; negative regulation of glutamate secretion; negative regulation of hormone secretion; negative regulation of leukocyte migration; negative regulation of lipid catabolic process; negative regulation of neurotrophin production; negative regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; negative regulation of vasodilation; nervous system development; neurological control of breathing; phagocytosis; positive regulation of blood pressure; positive regulation of epidermal growth factor receptor activity; positive regulation of nucleoside transport; positive regulation of peptide secretion; positive regulation of potassium ion transport; positive regulation of protein amino acid dephosphorylation; protein targeting to membrane; regulation of excitatory postsynaptic membrane potential; regulation of glomerular filtration; regulation of sensory perception of pain; relaxation of vascular smooth muscle; response to hypoxia; signal transduction; thermoregulation
Research Articles on ADORA1
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Products associated with ADORA1 elisa kit
Pathways associated with ADORA1 elisa kit
Diseases associated with ADORA1 elisa kit
Organs/Tissues associated with ADORA1 elisa kit
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