AAB18344.1
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UniProt Related Accession #
Molecular Weight
14,708 Da
NCBI Official Full Name
adipocyte fatty acid binding protein
NCBI Official Synonym Full Names
fatty acid binding protein 4, adipocyte
NCBI Official Synonym Symbols
NCBI Protein Information
fatty acid-binding protein, adipocyte; AFABP; A-FABP; fatty acid-binding protein 4; adipocyte lipid-binding protein; adipocyte-type fatty acid-binding protein
UniProt Protein Name
Fatty acid-binding protein, adipocyte
UniProt Synonym Protein Names
Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4
UniProt Synonym Gene Names
UniProt Entry Name
FABP4_RAT
NCBI Summary for aFABP
intracellular lipid-binding protein; mediates fatty acid trafficking during lipolysis [RGD, Feb 2006]
UniProt Comments for aFABP
FABP4: a lipid transport protein that is the predominant fatty acid binding protein found in adipocytes. Also expressed in macrophages. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Homodimer. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Interacts with PPARG. Monomer. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes. Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE. Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders. Belongs to the calycin superfamily,fatty-acid binding protein (FABP) family.
Protein type: Lipid-binding
Cellular Component: cytoplasm; lipid particle; cytosol; nucleus
Molecular Function: protein binding; transporter activity; fatty acid binding; lipid binding
Biological Process: response to drug; cholesterol homeostasis; transport; white fat cell differentiation; response to glucocorticoid stimulus; positive regulation of cell proliferation; brown fat cell differentiation; cytokine production; negative regulation of protein kinase activity; fatty acid metabolic process; negative regulation of transcription, DNA-dependent; positive regulation of inflammatory response
Research Articles on aFABP
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Pathways associated with aFABP elisa kit
Organs/Tissues associated with aFABP elisa kit
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