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AGER elisa kit :: Rat Advanced Glycosylation End Product Specific Receptor ELISA Kit

Scan QR to view Datasheet Catalog #    MBS730928
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Advanced Glycosylation End Product Specific Receptor (AGER), ELISA Kit

 Also Known As   

Rat Advanced Glycosylation End Product Specific Receptor ELISA Kit

 Product Gene Name   

AGER elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 OMIM    600214
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 Species Reactivity    Rat
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of AGER elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AGER purchase    MBS730928 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AGER. The ELISA analytical biochemical technique of the MBS730928 kit is based on AGER antibody-AGER antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AGER antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AGER. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for AGER elisa kit    Neurobiology
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 Typical Testing Data/Standard Curve (for reference only) of AGER elisa kit    AGER elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS730928
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NCBI/Uniprot data below describe general gene information for AGER. It may not necessarily be applicable to this product.
 NCBI GI #    18088363
 NCBI GeneID    177
 NCBI Accession #    AAH20669.1 [Other Products]
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 UniProt Secondary Accession #    Q15279; Q3L1R4; Q3L1R5; Q3L1R6; Q3L1R7; Q3L1R8; Q3L1S0; A2BFI7; A6NKF0; A7Y2U9; B0V176 [Other Products]
 UniProt Related Accession #    Q15109 [Other Products]
 Molecular Weight    41,098 Da
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 NCBI Official Full Name    Advanced glycosylation end product-specific receptor
 NCBI Official Synonym Full Names    advanced glycosylation end product-specific receptor
 NCBI Official Symbol    AGER [Similar Products]
 NCBI Official Synonym Symbols   
RAGE
[Similar Products]
 NCBI Protein Information    advanced glycosylation end product-specific receptor; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta; receptor for advanced glycation end-products variant 20
 UniProt Protein Name    Advanced glycosylation end product-specific receptor
 UniProt Synonym Protein Names   
Receptor for advanced glycosylation end products
 Protein Family    Advanced glycosylation end product-specific receptor
 UniProt Gene Name    AGER [Similar Products]
 UniProt Synonym Gene Names    RAGE [Similar Products]
 UniProt Entry Name    RAGE_HUMAN
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 NCBI Summary for AGER    The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
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 UniProt Comments for AGER    RAGE: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Interacts with S100B, S100A1 and APP. Interacts with S100A12. Endothelial cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis; Cell cycle regulation

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; receptor activity

Biological Process: cell surface receptor linked signal transduction; response to wounding; innate immune response; inflammatory response; neurite development; induction of positive chemotaxis; activation of NF-kappaB transcription factor
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 Research Articles on AGER    1. S100A13 interacts with the C2 domain of RAGE.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AGER elisa kitPathways associated with AGER elisa kit
 Reference Product  PubMed Publications
 RAGE elisa kit  >36 publications with AGER and RAGE
 HMG1 elisa kit  >4 publications with AGER and HMG1
 HMGB1 elisa kit  >4 publications with AGER and HMGB1
 S100B elisa kit  >2 publications with AGER and S100B
 MMP2 elisa kit  >2 publications with AGER and MMP2
 S100A12 elisa kit  >1 publications with AGER and S100A12
 CRP elisa kit  >1 publications with AGER and CRP
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88 Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88 Cascade Initiated On Plasma Membrane Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 MyD88-independent Cascade Pathway antibodies  MyD88-independent Cascade Pathway Diagram
Diseases associated with AGER elisa kitOrgans/Tissues associated with AGER elisa kit
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >34 publications with AGER and Lung Diseases
 Cardiovascular Diseases Antibodies  >33 publications with AGER and Cardiovascular Diseases
 Inflammation Antibodies  >30 publications with AGER and Inflammation
 Prenatal Exposure Delayed Effects Antibodies  >22 publications with AGER and Prenatal Exposure Delayed Effects
 Heart Diseases Antibodies  >18 publications with AGER and Heart Diseases
 Necrosis Antibodies  >13 publications with AGER and Necrosis
 Atherosclerosis Antibodies  >12 publications with AGER and Atherosclerosis
 Fibrosis Antibodies  >11 publications with AGER and Fibrosis
 Liver Diseases Antibodies  >10 publications with AGER and Liver Diseases
 Kidney Diseases Antibodies  >10 publications with AGER and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >33 publications with AGER and Lung
 Lymph Node Antibodies  >31 publications with AGER and Lymph Node
 Heart Antibodies  >17 publications with AGER and Heart
 Connective Tissue Antibodies  >12 publications with AGER and Connective Tissue
 Embryonic Tissue Antibodies  >10 publications with AGER and Embryonic Tissue
 Thymus Antibodies  >7 publications with AGER and Thymus
 Eye Antibodies  >6 publications with AGER and Eye
 Intestine Antibodies  >6 publications with AGER and Intestine
 Ovary Antibodies  >6 publications with AGER and Ovary
 Pancreas Antibodies  >4 publications with AGER and Pancreas
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