AAB21517.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,373 Da
NCBI Official Full Name
aldosterone synthase
NCBI Official Synonym Full Names
cytochrome P450, family 11, subfamily b, polypeptide 2
NCBI Protein Information
cytochrome P450 11B2, mitochondrial
UniProt Protein Name
Cytochrome P450 11B2, mitochondrial
UniProt Synonym Protein Names
Aldosterone synthase; CYPXIB2; Cytochrome P450C11; Steroid 11-beta-hydroxylase (EC:1.14.15.4, EC:1.14.15.5)
UniProt Synonym Gene Names
UniProt Entry Name
C11B2_MOUSE
UniProt Comments for ALDOS
CYP11B2: Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone. Defects in CYP11B2 are the cause of corticosterone methyloxidase type 1 deficiency (CMO-1 deficiency); also known as aldosterone deficiency due to defect in 18- hydroxylase or aldosterone deficiency I. CMO-1 deficiency is an autosomal recessive disorder of aldosterone biosynthesis. There are two biochemically different forms of selective aldosterone deficiency be termed corticosterone methyloxidase (CMO) deficiency type 1 and type 2. In CMO-1 deficiency, aldosterone is undetectable in plasma, while its immediate precursor, 18- hydroxycorticosterone, is low or normal. Defects in CYP11B2 are the cause of corticosterone methyloxidase type 2 deficiency (CMO-2 deficiency). CMO-2 is an autosomal recessive disorder of aldosterone biosynthesis. In CMO-2 deficiency, aldosterone can be low or normal, but at the expense of increased secretion of 18- hydroxycorticosterone. Consequently, patients have a greatly increased ratio of 18-hydroxycorticosterone to aldosterone and a low ratio of corticosterone to 18-hydroxycorticosterone in serum. Defects in CYP11B2 are a cause of familial hyperaldosteronism type 1 (FH1). It is a disorder characterized by hypertension, variable hyperaldosteronism, and abnormal adrenal steroid production, including 18-oxocortisol and 18-hydroxycortisol. There is significant phenotypic heterogeneity, and some individuals never develop hypertension. The molecular defect causing hyperaldosteronism familial type 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2. Belongs to the cytochrome P450 family.
Protein type: Lipid Metabolism - androgen and estrogen; EC 1.14.15.5; Mitochondrial; EC 1.14.15.4; Lipid Metabolism - C21-steroid hormone; Oxidoreductase
Cellular Component: membrane; mitochondrion; dendrite
Molecular Function: corticosterone 18-monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; steroid 11-beta-monooxygenase activity; iron ion binding; metal ion binding; heme binding; oxidoreductase activity; monooxygenase activity
Biological Process: regulation of systemic arterial blood pressure by circulatory renin-angiotensin; ion homeostasis; regulation of blood pressure; drinking behavior; C21-steroid hormone biosynthetic process; aldosterone mediated regulation of blood volume; glucocorticoid biosynthetic process; steroid biosynthetic process; aldosterone biosynthetic process; positive regulation of blood pressure
Research Articles on ALDOS
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Products associated with ALDOS elisa kit
Pathways associated with ALDOS elisa kit
Products by Pathway |
Pathway Diagram |
Biological Oxidations Pathway antibodies |
Biological Oxidations Pathway Diagram |
C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway antibodies |
C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway Diagram |
C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway antibodies |
C21-Steroid Hormone Biosynthesis, Progesterone => Corticosterone/aldosterone Pathway Diagram |
C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies |
C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram |
C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies |
C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram |
Cytochrome P450 Pathway antibodies |
Cytochrome P450 Pathway Diagram |
Cytochrome P450 - Arranged By Substrate Type Pathway antibodies |
Cytochrome P450 - Arranged By Substrate Type Pathway Diagram |
Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway antibodies |
Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway Diagram |
Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway antibodies |
Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway Diagram |
Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway antibodies |
Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway Diagram |
Diseases associated with ALDOS elisa kit
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