Q9C0B1.3
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,218 Da
NCBI Official Full Name
Alpha-ketoglutarate-dependent dioxygenase FTO
NCBI Official Synonym Full Names
fat mass and obesity associated
NCBI Official Synonym Symbols
NCBI Protein Information
alpha-ketoglutarate-dependent dioxygenase FTO; protein fto; AlkB homolog 9; fat mass and obesity-associated protein
UniProt Protein Name
Alpha-ketoglutarate-dependent dioxygenase FTO
UniProt Synonym Protein Names
Fat mass and obesity-associated protein
UniProt Synonym Gene Names
UniProt Entry Name
FTO_HUMAN
NCBI Summary for FTO
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
UniProt Comments for FTO
FTO: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD). A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years. Belongs to the fto family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.-
Chromosomal Location of Human Ortholog: 16q12.2
Cellular Component: nuclear speck; nucleus
Molecular Function: ferrous iron binding; DNA-N1-methyladenine dioxygenase activity
Biological Process: DNA dealkylation; RNA repair; regulation of multicellular organism growth; thermoregulation
Disease: Growth Retardation, Developmental Delay, Coarse Facies, And Early Death
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Products associated with FTO elisa kit
Diseases associated with FTO elisa kit
Organs/Tissues associated with FTO elisa kit
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