NP_036934.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
122,642 Da
NCBI Official Full Name
platelet-derived growth factor receptor alpha
NCBI Official Synonym Full Names
platelet derived growth factor receptor alpha
NCBI Protein Information
platelet-derived growth factor receptor alpha
UniProt Protein Name
Platelet-derived growth factor receptor alpha
UniProt Synonym Protein Names
Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; Platelet-derived growth factor alpha receptor; CD_antigen: CD140a
UniProt Synonym Gene Names
UniProt Entry Name
PGFRA_RAT
NCBI Summary for Pdgfra
acts as a receptor tyrosine kinase for PDGF; may play a role in glial cell generation [RGD, Feb 2006]
UniProt Comments for Pdgfra
PDGFRA: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation. Particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. Chromosomal rearrangments activate PDGFRalpha by fusion to BCR, causing atypical chronic myelogenous leukemia (CML), and to FIP1L1, causing idiopathic hypereosinophilic syndrome. Activating point mutations cause a minority of gastrointestinal stromal tumors (GIST). Promoter polymorphisms linked to neural tube defects including spina bifida, verified by mouse mutant model. Inhibitors: Gleevec, Sutent. OMIM: Two alternatively-spliced isoforms have been described.
Protein type: Kinase, protein; Oncoprotein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; PDGFR family
Cellular Component: cell surface; cytoplasm; cytosol; external side of plasma membrane; integral to membrane; integral to plasma membrane; intrinsic to plasma membrane; membrane; microvillus; nucleus; plasma membrane; protein complex
Molecular Function: ATP binding; phosphoinositide 3-kinase binding; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein complex binding; protein dimerization activity; protein homodimerization activity; protein kinase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity
Biological Process: adrenal gland development; anatomical structure morphogenesis; cardiac myofibril assembly; cell migration; chemotaxis; elevation of cytosolic calcium ion concentration; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic skeletal morphogenesis; estrogen metabolic process; extracellular matrix organization and biogenesis; female gonad development; gliogenesis; hemopoietic progenitor cell differentiation; in utero embryonic development; inner ear development; Leydig cell differentiation; lung development; luteinization; male genitalia development; odontogenesis of dentine-containing teeth; organ morphogenesis; palate development; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of fibroblast proliferation; positive regulation of phosphoinositide 3-kinase activity; protein amino acid autophosphorylation; regulation of chemotaxis; response to cytokine stimulus; response to estradiol stimulus; response to estrogen stimulus; response to hormone stimulus; response to hyperoxia; response to inorganic substance; response to organic substance; skeletal morphogenesis; wound healing
Research Articles on Pdgfra
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Products associated with Pdgfra elisa kit
Pathways associated with Pdgfra elisa kit
Diseases associated with Pdgfra elisa kit
Organs/Tissues associated with Pdgfra elisa kit
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